人8-氧代鸟嘌呤DNA糖基化酶1（hOGG1）丝氨酸326位半胱氨酸多态性与肝细胞癌之间无关联。

No association between hOGG1 Ser326Cys polymorphism and hepatocellular carcinoma.

作者信息

Zhen-Bo Tu, An-Lin Feng, Ling Li, Su-Fang Zhou

出版信息

Hepatogastroenterology. 2013 Jul-Aug;60(125):1101-4. doi: 10.5754/hge12909.

Abstract

BACKGROUND/AIMS: To clarify any association between the hOGG1 Ser326Cys polymorphism and susceptibility to hepatocellular carcinoma (HCC).

METHODOLOGY

The PubMed, CNKI databases were searched for all available articles. The OR corresponding to the 95% confidence interval (95% CI) was used to assess the association between hOGG1 Ser326Cys polymorphism and susceptibility to HCC.

RESULTS

Seven case-control studies, with 1,663 cases and 1,675 controls, were available for this analysis. No association was found between hOGG1 Ser326Cys polymorphism and HCC risk (dominant model: OR=0.695, 95% CI: 0.501-0.964, p=0.029; additive model: OR=0.682, 95% CI: 0.374-1.245, p=0.213; recessive model: OR=1.215, 95% CI: 0.711-2.078, p=0.476). Sensitivity analysis did not perturb the results.

CONCLUSIONS

These findings indicated that hOGG1 Ser326Cys polymorphism may not play a role in HCC development. However, larger scale studies are needed for confirmation.

摘要

背景/目的：阐明人8-氧代鸟嘌呤DNA糖基化酶1（hOGG1）丝氨酸326位密码子突变为半胱氨酸（Ser326Cys）多态性与肝细胞癌（HCC）易感性之间的任何关联。

方法

检索PubMed和中国知网数据库中的所有可用文章。使用对应95%置信区间（95%CI）的比值比（OR）评估hOGG1 Ser326Cys多态性与HCC易感性之间的关联。

结果

本分析纳入7项病例对照研究，共1663例病例和1675例对照。未发现hOGG1 Ser326Cys多态性与HCC风险之间存在关联（显性模型：OR = 0.695，95%CI：0.501 - 0.964，p = 0.029；加性模型：OR = 0.682，95%CI：0.374 - 1.245，p = 0.213；隐性模型：OR = 1.215，95%CI：0.711 - 2.078，p = 0.476）。敏感性分析未干扰结果。