Ikeda Chika, Abe Tomoki, Sakai Atsuko, Hirasaka Katsuya, Nikawa Takeshi
Department of Nutritional Physioloy, Institute of Health Biosciences, University of Tokushima Graduate School, Japan.
Clin Calcium. 2012 Dec;22(12):1813-20.
Muscle atrophy caused by unloading stress is a challenging problem for bed-rested patients or astronauts. However, countermeasures against these muscle atrophy have not been developed yet. Under unloading conditions, skeletal muscle mass is rapidly lost by the increase in protein breakdown and the decrease in protein synthesis. It has been shown that this enhancement of proteolysis in atrophying muscles results mainly from activation of the ubiquitin-proteasome proteolytic pathway. Previous our studies revealed that unloading stress led to skeletal muscle atrophy through the induction of ubiquitin ligase, Cbl-b (Casitas B-lineage lymphoma b) expression. Thus, Cbl-b inhibiters may be potent therapeutic and preventive sources against skeletal muscle atrophy caused by unloading stress.
由失重应激引起的肌肉萎缩对于卧床患者或宇航员来说是一个具有挑战性的问题。然而，针对这些肌肉萎缩的对策尚未研发出来。在失重条件下，骨骼肌质量会因蛋白质分解增加和蛋白质合成减少而迅速流失。研究表明，萎缩肌肉中蛋白水解作用的增强主要源于泛素-蛋白酶体蛋白水解途径的激活。我们之前的研究表明，失重应激通过诱导泛素连接酶Cbl-b（Casitas B系淋巴瘤b）的表达导致骨骼肌萎缩。因此，Cbl-b抑制剂可能是对抗失重应激引起的骨骼肌萎缩的有效治疗和预防手段。
