Endo Itsuro, Matsumoto Toshio
Department of Medicine and Bioregulatory Sciences, The University of Tokushima Graduate School of Medical Sciences, Japan.
Clin Calcium. 2012 Dec;22(12):1863-70.
Bone mass and strength are maintained by appropriate weight bearing. The loss of bone mineral due to space flight or prolonged bed rest has been recognized by space scientists and physicians. In spite of the wealth of knowledge obtained thus far, many questions remain unanswered regarding the mechanism of bone loss as well as the factors affecting these skeletal processes. Bisphosphonates have a potential to become countermeasures against space flight-induced or disuse osteoporosis. In this review, the effect and the possible role of biphosphonates on the prevention and treatment of unloading-induced osteoporosis are summarized and future prospects are discussed.
骨量和骨强度通过适当的负重得以维持。太空科学家和医生已经认识到，太空飞行或长期卧床休息会导致骨矿物质流失。尽管迄今为止已获得了丰富的知识，但关于骨质流失的机制以及影响这些骨骼过程的因素，仍有许多问题尚未得到解答。双膦酸盐有潜力成为对抗太空飞行诱导或废用性骨质疏松症的对策。在这篇综述中，总结了双膦酸盐在预防和治疗失重诱导的骨质疏松症方面的作用及可能机制，并讨论了未来前景。
