Kinoshita Yuka, Fukumoto Seiji
Division of Nephrology & Endocrinology, Department of Medicine, University of Tokyo Hospital, Japan.
Clin Calcium. 2012 Dec;22(12):1895-901.
Immobilization or unloading results in rapid bone loss by both enhanced bone resorption and suppressed bone formation. Bisphosphonates have been used to treat immobilization osteoporosis to suppress increased bone resorption. Recently, parathyroid hormone and anti-sclerostin antibody have been shown to enhance bone formation in immobilized or unloaded animal models. It is possible that these anabolic agents will be good alternatives for immobilization osteoporosis.
制动或失用会通过增强骨吸收和抑制骨形成导致快速的骨质流失。双膦酸盐已被用于治疗制动性骨质疏松症以抑制增加的骨吸收。最近，甲状旁腺激素和抗硬化蛋白抗体已被证明在制动或失用的动物模型中可增强骨形成。这些促合成代谢药物有可能成为治疗制动性骨质疏松症的良好替代药物。
