Millward T A, Wilson M
Department of Clinical Pathology and Immunology, Institute of Dental Surgery, London, UK.
J Antimicrob Chemother. 1990 Jan;25(1):31-7. doi: 10.1093/jac/25.1.31.
Bacteroides gingivalis was grown in the presence of chlorhexidine at concentrations lower than the minimum inhibitory concentration (1.25 mg/l). These sub-inhibitory concentrations were found to stimulate growth in terms of an increase in the number of viable cells, the greatest increase being at a concentration of 0.75 mg/l of chlorhexidine. The total proteolytic activity of the cultures (assayed by means of azocasein hydrolysis) grown in the presence of chlorhexidine and their specific activities (per 10(6) cells) were found to be less than those of the cultures grown in the absence of chlorhexidine. In the case of the trypsin-like activity of the microorganism, a different pattern was found. Thus, although the specific activities of the chlorhexidine-grown cultures were lower than those of the chlorhexidine-free cultures, the total activity in the chlorhexidine-grown cultures was greater.
牙龈拟杆菌在低于最低抑菌浓度（1.25毫克/升）的洗必泰存在下生长。发现这些亚抑制浓度可通过活细胞数量的增加来刺激生长，在洗必泰浓度为0.75毫克/升时增加最为显著。在洗必泰存在下培养的培养物的总蛋白水解活性（通过偶氮酪蛋白水解测定）及其比活性（每10^6个细胞）低于在无洗必泰条件下培养的培养物。对于该微生物的类胰蛋白酶活性，发现了不同的模式。因此，尽管在洗必泰存在下培养的培养物的比活性低于无洗必泰培养的培养物，但在洗必泰存在下培养的培养物中的总活性更高。
