Orwoll E S, Oviatt S K, Mann T
Portland Veterans Administration Medical Center, Oregon 97207.
J Clin Endocrinol Metab. 1990 Apr;70(4):1202-7. doi: 10.1210/jcem-70-4-1202.
To evaluate the influence of extravertebral calcification on spinal bone density determinations, we measured lumbar vertebral density in 71 hospitalized and 58 normal men using dual photon absorptiometry. The extent of vascular and osteophytic calcification was graded from lateral lumbar radiographs. Fifty-five (43%) of the subjects had identifiable osteophytes, and 86 (67%) had vascular calcifications. Despite similar ages and weights in subjects with and without ostephytes, those with osteophytes had greater spinal density (1.34 vs. 1.17 g/cm2; P less than 0.001), and there was a strong correlation between osteophyte severity and spinal density (r = 0.41; P less than 0.00001). Proximal femoral density was not different in those with and without osteophytes. The distribution of osteophytes in this population was not random, and as a result, the presence of osteophytes obscured the the relationship of bone density to age as well as the comparison of hospitalized to normal men. Vascular calcification had a minimal effect on vertebral density. In summary, osteophytic calcification exerted an important influence on the measurement of spinal bone density in men. This effect should be considered in both clinical and research applications of integral vertebral density measures.
为评估椎体外钙化对脊柱骨密度测定的影响，我们使用双能光子吸收法对71名住院男性和58名正常男性的腰椎密度进行了测量。从腰椎侧位X线片对血管和骨赘钙化程度进行分级。55名（43%）受试者有可识别的骨赘，86名（67%）有血管钙化。尽管有和没有骨赘的受试者年龄和体重相似，但有骨赘者的脊柱密度更高（1.34对1.17g/cm²；P<0.001），且骨赘严重程度与脊柱密度之间存在强相关性（r=0.41；P<0.00001）。有和没有骨赘者的股骨近端密度无差异。该人群中骨赘的分布并非随机，因此，骨赘的存在掩盖了骨密度与年龄的关系以及住院男性与正常男性之间的比较。血管钙化对椎体密度影响极小。总之，骨赘钙化对男性脊柱骨密度测量有重要影响。在椎体整体密度测量的临床和研究应用中均应考虑这种影响。
