Krauss E A, Ludwig P W, Sumner H W
Am J Gastroenterol. 1979 Dec;72(6):651-4.
An unusual cause of fulminant hepatic failure is described. The patient, who presented with symptoms of liver disease, proved to have a small primary oat cell carcinoma of the lung with massive hepatic metastases. The clinical evolution was rapid, with marked elevations of SGOT (this without a prior hypotensive episode) and hepatic coma. Examination of the liver showed two types of necrosis: 1. infarction secondary to multiple tumor emboli in portal vessels and 2. overrunning of hepatic cell plates by expanding masses of tumor cells (somewhat analogous to piecemeal necrosis).
描述了暴发性肝衰竭的一种罕见病因。该患者表现出肝脏疾病症状，经证实患有肺小原发性燕麦细胞癌并伴有大量肝转移。临床进展迅速，血清谷草转氨酶显著升高（此前无低血压发作）并出现肝昏迷。肝脏检查显示两种坏死类型：1. 门静脉多个肿瘤栓子继发的梗死；2. 肿瘤细胞团块扩展致使肝细胞板被侵蚀（ somewhat analogous to piecemeal necrosis，此处原英文表述有误，piecemeal necrosis应译为“桥接坏死”，整体应译为“肿瘤细胞团块扩展致使肝细胞板被侵蚀（类似于桥接坏死）” ） 。
