Department of Pathology, Massachusetts General Hospital, Boston, USA.
Arch Pathol Lab Med. 2012 Dec;136(12):1492-501. doi: 10.5858/arpa.2012-0252-SA.
Optical coherence tomography (OCT) is a nondestructive, high-resolution imaging modality, providing cross-sectional, architectural images at near histologic resolutions, with penetration depths up to a few millimeters. Optical frequency domain imaging is a second-generation OCT technology that has equally high resolution with significantly increased image acquisition speeds and allows for large area, high-resolution tissue assessments. These features make OCT and optical frequency domain imaging ideal imaging techniques for surface and endoscopic imaging, specifically when tissue is unsafe to obtain and/or suffers from biopsy sampling error. This review focuses on the clinical impact of OCT in coronary, esophageal, and pulmonary imaging and the role of the pathologist in interpreting high-resolution OCT images as a complement to standard tissue pathology.
光学相干断层扫描（OCT）是一种无损、高分辨率的成像方式，可提供接近组织学分辨率的横截面、结构图像，穿透深度可达数毫米。光学频域成像（OFD）是第二代 OCT 技术，具有同样的高分辨率，显著提高了图像采集速度，并可进行大面积、高分辨率的组织评估。这些特性使 OCT 和 OFD 成为表面和内窥镜成像的理想成像技术，特别是在获取组织不安全和/或存在活检取样误差时。本综述重点介绍了 OCT 在冠状动脉、食管和肺部成像中的临床应用，以及病理学家在解释高分辨率 OCT 图像方面的作用，作为对标准组织病理学的补充。
