线性阵列 HPV 基因分型的可重复性。
Reproducibility of linear array for human papillomavirus genotyping.
机构信息
Division of Cancer Epidemiology and Genetics, NCI/NIH/DHHS, Bethesda, Maryland, USA.
出版信息
J Clin Microbiol. 2013 Feb;51(2):625-8. doi: 10.1128/JCM.03036-12. Epub 2012 Nov 28.
Abstract
We conducted a Linear Array test/retest analysis using cytologic specimens from 198 women. A total of 67.2% of samples had the same human papillomavirus (HPV) types detected in both tests (type-specific positive agreement was 83.3% overall [Kappa = 0.9] and 86.8% for carcinogenic types [Kappa = 0.92]). Discordance was highest with a low hybridization signal strength. Overall, Linear Array was highly reproducible.
摘要
我们对 198 名女性的细胞学标本进行了线性阵列检测/重复检测分析。在这两项检测中，有 67.2%的样本检测到相同的人乳头瘤病毒（HPV）类型（总的 HPV 型别阳性一致性为 83.3%[Kappa=0.9]，致癌型别阳性一致性为 86.8%[Kappa=0.92]）。杂交信号强度低时，不一致性最高。总体而言，线性阵列具有高度的可重复性。
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