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本文引用的文献

1
Mesenchymal Stem Cells: The Past, the Present, the Future.间充质干细胞:过去、现在与未来
Cartilage. 2010 Jan;1(1):6-9. doi: 10.1177/1947603509354992.
2
Past, present and future of myoblast transplantation in the treatment of Duchenne muscular dystrophy.成肌细胞移植治疗杜氏肌营养不良症的过去、现在与未来
Pediatr Transplant. 2010 Nov;14(7):813-9. doi: 10.1111/j.1399-3046.2010.01377.x.
3
Geron trial resumes, but standards for stem cell trials remain elusive.杰龙公司的试验重新开始,但干细胞试验的标准仍然难以确定。
Nat Biotechnol. 2010 Oct;28(10):989-90. doi: 10.1038/nbt1010-989.
4
Regenerative medicine. Opportunities and challenges: a brief overview.再生医学。机遇与挑战:简要概述。
J R Soc Interface. 2010 Dec 6;7 Suppl 6(Suppl 6):S777-81. doi: 10.1098/rsif.2010.0362.focus. Epub 2010 Sep 8.
5
Developing a case study model for successful translation of stem cell therapies.开发一个成功的干细胞疗法翻译案例研究模型。
Cell Stem Cell. 2010 Jun 4;6(6):513-6. doi: 10.1016/j.stem.2010.05.008.
6
Challenges with advanced therapy medicinal products and how to meet them.治疗性药品面临的挑战及其应对措施。
Nat Rev Drug Discov. 2010 Mar;9(3):195-201. doi: 10.1038/nrd3052.
7
Stem cells: roadmap to the clinic.干细胞:通往临床的路线图。
J Clin Invest. 2010 Jan;120(1):8-10. doi: 10.1172/JCI41801.
8
Successful clinical implementation of corneal epithelial stem cell therapy for treatment of unilateral limbal stem cell deficiency.成功地将角膜上皮干细胞治疗应用于单侧角膜缘干细胞缺陷的临床治疗。
Stem Cells. 2010 Mar 31;28(3):597-610. doi: 10.1002/stem.276.
9
Assessing the value of autologous and allogeneic cells for regenerative medicine.评估自体和异体细胞在再生医学中的价值。
Regen Med. 2009 Nov;4(6):835-53. doi: 10.2217/rme.09.64.
10
Human cell culture process capability: a comparison of manual and automated production.人细胞培养工艺能力:手动与自动化生产的比较。
J Tissue Eng Regen Med. 2010 Jan;4(1):45-54. doi: 10.1002/term.217.

简明回顾:细胞疗法:广泛应用的途径。

Concise review: cell therapies: the route to widespread adoption.

机构信息

Newcastle University Business School, Citywall, Citygate, Newcastle Upon Tyne, United Kingdom.

出版信息

Stem Cells Transl Med. 2012 May;1(5):438-47. doi: 10.5966/sctm.2011-0009. Epub 2012 May 9.

DOI:10.5966/sctm.2011-0009
PMID:23197823
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3659704/
Abstract

We identify three dimensions with which to classify heuristically the routes to widespread adoption of cellular therapies. The first dimension is based on the relative involvement of clinicians and companies in a particular cellular therapy. The second dimension is based on cell type and consequent scale of manufacture. The third dimension classifies the therapeutic intervention as a procedure or product and has perhaps received less attention. We suggest that for those cellular therapies that require therapeutic procedures, close collaboration between companies and clinicians will reduce the time to widespread adoption. For selected cellular therapies we make predictions of the likely time to widespread adoption.

摘要

我们确定了三个维度,可以对细胞疗法广泛应用的途径进行启发式分类。第一个维度基于临床医生和公司在特定细胞疗法中的相对参与程度。第二个维度基于细胞类型和随后的制造规模。第三个维度将治疗干预分为程序或产品,可能受到的关注较少。我们认为,对于那些需要治疗程序的细胞疗法,公司和临床医生之间的密切合作将缩短广泛采用的时间。对于某些选定的细胞疗法,我们对广泛采用的可能时间进行了预测。