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再生医学。机遇与挑战:简要概述。

Regenerative medicine. Opportunities and challenges: a brief overview.

机构信息

Faculty of Medicine, Regenerative Medicine, Department of Chemical Engineering, Imperial College London, South Kensington Campus, Room 144, Roderic Hill Building, London SW7 2AZ, UK.

出版信息

J R Soc Interface. 2010 Dec 6;7 Suppl 6(Suppl 6):S777-81. doi: 10.1098/rsif.2010.0362.focus. Epub 2010 Sep 8.

DOI:10.1098/rsif.2010.0362.focus
PMID:20826477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2988280/
Abstract

Regenerative medicine is a new multi-disciplinary field aiming at the repair or replacement of disease body parts. The field is progressing at an unprecedented pace and although the opportunities are immense, many hurdles lie ahead. This brief review analyses the opportunities and challenges faced by regenerative medicine.

摘要

再生医学是一个旨在修复或替换疾病部位的新的多学科领域。该领域正以前所未有的速度发展,尽管机会巨大,但仍面临许多障碍。本文简要分析了再生医学所面临的机遇和挑战。

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Regenerative medicine. Opportunities and challenges: a brief overview.再生医学。机遇与挑战:简要概述。
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本文引用的文献

1
Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells.在小鼠诱导多能干细胞中,12qF1 染色体上的印迹基因异常沉默。
Nature. 2010 May 13;465(7295):175-81. doi: 10.1038/nature09017. Epub 2010 Apr 25.
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Breaking ground on translational stem cell research.开拓转化干细胞研究新领域。
Ann N Y Acad Sci. 2010 Mar;1189 Suppl 1:E1-15. doi: 10.1111/j.1749-6632.2010.05495.x.
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Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency.人类诱导多能干细胞的神经分化遵循发育原则,但具有可变的潜能。
Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4335-40. doi: 10.1073/pnas.0910012107. Epub 2010 Feb 16.
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Hemangioblastic derivatives from human induced pluripotent stem cells exhibit limited expansion and early senescence.人诱导多能干细胞的血管母细胞衍生物表现出有限的扩增和早期衰老。
Stem Cells. 2010 Apr;28(4):704-12. doi: 10.1002/stem.321.
5
Successful clinical implementation of corneal epithelial stem cell therapy for treatment of unilateral limbal stem cell deficiency.成功地将角膜上皮干细胞治疗应用于单侧角膜缘干细胞缺陷的临床治疗。
Stem Cells. 2010 Mar 31;28(3):597-610. doi: 10.1002/stem.276.
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A safer stem cell: inducing pluripotency.一种更安全的干细胞:诱导多能性。
Nat Med. 2009 Sep;15(9):1001-2. doi: 10.1038/nm0909-1001.
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Linking the p53 tumour suppressor pathway to somatic cell reprogramming.将p53肿瘤抑制通路与体细胞重编程联系起来。
Nature. 2009 Aug 27;460(7259):1140-4. doi: 10.1038/nature08311. Epub 2009 Aug 9.
8
Comparative materials differences revealed in engineered bone as a function of cell-specific differentiation.作为细胞特异性分化的函数,工程骨中揭示的比较材料差异。
Nat Mater. 2009 Sep;8(9):763-70. doi: 10.1038/nmat2505. Epub 2009 Jul 26.
9
Induced pluripotent stem cells and embryonic stem cells are distinguished by gene expression signatures.诱导多能干细胞和胚胎干细胞通过基因表达特征来区分。
Cell Stem Cell. 2009 Jul 2;5(1):111-23. doi: 10.1016/j.stem.2009.06.008.
10
Stem cell bioprocessing: fundamentals and principles.干细胞生物加工:基础与原理
J R Soc Interface. 2009 Mar 6;6(32):209-32. doi: 10.1098/rsif.2008.0442.