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本文引用的文献

1
A correlation found between contact allergy to stent material and restenosis of the coronary arteries.发现对支架材料的接触性过敏与冠状动脉再狭窄之间存在相关性。
Contact Dermatitis. 2009 Mar;60(3):158-64. doi: 10.1111/j.1600-0536.2008.01502.x.
2
Metal allergic reaction in chronic refractory in-stent restenosis.慢性难治性支架内再狭窄中的金属过敏反应。
Cardiovasc Revasc Med. 2009 Jan-Mar;10(1):17-22. doi: 10.1016/j.carrev.2008.01.004.
3
Hypersensitivity reactions associated with endovascular devices.与血管内装置相关的超敏反应。
Contact Dermatitis. 2008 Jul;59(1):7-22. doi: 10.1111/j.1600-0536.2008.01351.x. Epub 2008 Jun 1.
4
Prevalence of patch test results from 1970 to 2002 in a multi-centre population in North America (NACDG).
Contact Dermatitis. 2008 Feb;58(2):101-6. doi: 10.1111/j.1600-0536.2007.01281.x.
5
The impact of metallic allergy on stent implantation: metal allergy and recurrence of in-stent restenosis.金属过敏对支架植入的影响：金属过敏与支架内再狭窄的复发
Int J Cardiol. 2005 Oct 10;104(3):319-25. doi: 10.1016/j.ijcard.2004.12.034.
6
Is there a link between nickel allergy and coronary stent restenosis?镍过敏与冠状动脉支架再狭窄之间存在关联吗？
Tohoku J Exp Med. 2005 Jul;206(3):243-6. doi: 10.1620/tjem.206.243.
7
Thiazolidinedione treatment attenuates diffuse neointimal hyperplasia in restenotic lesions after coronary stent implantation in type 2 diabetic patients: an intravascular ultrasound study.
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Effect of vascular stent alloys on expression of cellular adhesion molecules by endothelial cells.血管支架合金对内皮细胞黏附分子表达的影响。
J Long Term Eff Med Implants. 2005;15(1):39-47. doi: 10.1615/jlongtermeffmedimplants.v15.i1.50.
9
Evaluation of metal allergies in patients with coronary stents.冠状动脉支架植入患者金属过敏的评估
Contact Dermatitis. 2002 Dec;47(6):353-6. doi: 10.1034/j.1600-0536.2002.470607.x.
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Relating nickel-induced tissue inflammation to nickel release in vivo.
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使用钴铬合金支架治疗的患者中镍过敏与支架内再狭窄的关系。

Relation of Nickel Allergy with in-Stent Restenosis in Patients Treated with Cobalt Chromium Stents.

作者信息

Aliağaoğlu Cihangir, Turan Hakan, Erden Ismail, Albayrak Hülya, Ozhan Hakan, Başar Cengiz, Gürlevik Zehra, Alçelik Ayşegül

机构信息

Department of Dermatology, Duzce University Medical Faculty, Duzce, Turkey.

出版信息

Ann Dermatol. 2012 Nov;24(4):426-9. doi: 10.5021/ad.2012.24.4.426. Epub 2012 Nov 8.

DOI:10.5021/ad.2012.24.4.426
PMID:23197908
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3505773/
Abstract

BACKGROUND

In-stent restenosis (ISR) is the major limitation of percutaneous coronary stenting procedure. The elements like nickel, chromate and molybdenum are known to cause contact allergy. Hypersensitivity reaction, against these metal ions, may be one of the reasons of ISR. Cobalt chromium coronary stents, which are increasingly being used in percutaneous coronary interventions, have more nickel amount than the stainless steel stents.

OBJECTIVE

We aimed to investigate the association between nickel hypersensitivity reaction and ISR in patients treated with cobalt chromium coronary stents.

METHODS

Epicutaneous patch tests for nickel were applied to 31 patients who had undergone elective cobalt chromium coronary stent implantation and had ISR in control angiogram. Thirty patients, without ISR, were included as the control group. Patch test results and other clinical variables were compared.

RESULTS

There was no statistically significant difference of the mean age, sex, body mass index, rate of hypercholesterolemia, diabetes, hypertension and smoking between the patients with and without ISR. All other lesion characteristics were similar in the 2 groups. According to the patch test results, 7 patients had nickel contact allergy. All of these patients were in the ISR group, which was statistically significant (p<0.006).

CONCLUSION

Patients treated with cobalt chromium coronary stents and had ISR were found to have significantly more nickel allergy than the control group. Nickel allergy may play role in restenosis pathophysiology.

摘要

背景

支架内再狭窄（ISR）是经皮冠状动脉支架置入术的主要局限性。已知镍、铬酸盐和钼等元素会引起接触性过敏。针对这些金属离子的超敏反应可能是ISR的原因之一。在经皮冠状动脉介入治疗中越来越多地使用的钴铬冠状动脉支架比不锈钢支架含有更多的镍。

目的

我们旨在研究接受钴铬冠状动脉支架治疗的患者中镍超敏反应与ISR之间的关联。

方法

对31例行择期钴铬冠状动脉支架置入术且在对照血管造影中存在ISR的患者进行镍的表皮斑贴试验。30例无ISR的患者作为对照组。比较斑贴试验结果和其他临床变量。

结果

有ISR和无ISR的患者在平均年龄、性别、体重指数、高胆固醇血症、糖尿病、高血压和吸烟率方面无统计学显著差异。两组的所有其他病变特征相似。根据斑贴试验结果，7例患者有镍接触性过敏。所有这些患者均在ISR组，具有统计学显著性（p<0.006）。

结论

发现接受钴铬冠状动脉支架治疗且发生ISR的患者比对照组有明显更多的镍过敏。镍过敏可能在再狭窄病理生理学中起作用。