Slodownik D, Danenberg C, Merkin D, Swaid F, Moshe S, Ingber A, Lotan H, Durst R
Department of Dermatology, Hadassah Hebrew University Medical Centre, Jerusalem, Israel. Email:
Cardiology Division, Hadassah Hebrew University Medical Centre, Jerusalem, Israel.
Cardiovasc J Afr. 2018;29(1):43-45. doi: 10.5830/CVJA-2017-036. Epub 2018 Jan 24.
Most intra-coronary stents in use are made of 316 L stainless steel, which contains nickel, chromate and molybdenum. Whether inflammatory and allergic reactions to metals contribute to in-stent restenosis is still a matter of debate.
The aim of this study was to ascertain the relationship between metal allergy and the occurrence of in-stent restenosis.
Ninety-nine adult patients who underwent two cardiac catheterisations, up to two years apart, were included in the study. Seventy patients had patent stents at the second angiogram (patent stent group) and 29 were found to have in-stent restenosis (restenosis group). All patients underwent patch testing with the relevant metals and the 316L stainless steel plate.
Twenty-eight (28.3%) patients were found to have an allergy to at least one metal. There was no significant difference in the prevalence of metal allergy between the patent stent group and the restenosis group (28.6 and 27.6%, respectively; p = 0.921).
Our data do not support the theory that contact allergy plays a role in the pathogenesis of in-stent restenosis.
目前使用的大多数冠状动脉支架由316L不锈钢制成，其中含有镍、铬酸盐和钼。金属引发的炎症和过敏反应是否会导致支架内再狭窄仍存在争议。
本研究旨在确定金属过敏与支架内再狭窄发生之间的关系。
本研究纳入了99例成年患者，这些患者在长达两年的时间里接受了两次心导管检查。在第二次血管造影时，70例患者的支架通畅（通畅支架组），29例被发现存在支架内再狭窄（再狭窄组）。所有患者均接受了相关金属和316L不锈钢板的斑贴试验。
发现28例（28.3%）患者对至少一种金属过敏。通畅支架组和再狭窄组之间的金属过敏患病率无显著差异（分别为28.6%和27.6%；p = 0.921）。
我们的数据不支持接触性过敏在支架内再狭窄发病机制中起作用这一理论。
