道瑞辛能够抑制尿路肿瘤细胞的增殖活性。
Dauricine can inhibit the activity of proliferation of urinary tract tumor cells.
机构信息
Department of Urology, Xiangya Hospital, Central South University, Changsha Hunan Province, China.
出版信息
Asian Pac J Trop Med. 2012 Dec;5(12):973-6. doi: 10.1016/S1995-7645(12)60185-0.
OBJECTIVE
To explore the anti-tumor effects of asiatic moonseed rhizome extraction-dauricine on bladder cancer EJ cell strain, prostate cancer PC-3Mcell strain and primary cell culture system.
METHODS
The main effective component-phenolic alkaloids ofMenispermum dauricum was extracted and separated from asiatic moonseed rhizome by chemical method. MTT method was used to detect dauricine anti-tumor effect.
RESULTS
Dauricine had an obvious proliferation inhibition effect on the main tumor cells in urinary system. The minimum drug sensitivity concentration was between 3.81-5.15 μg/mL, and the inhibition ratio increased with the increase of concentration.
CONCLUSIONS
Dauricine, the main effective component extracted from asiatic moonseed rhizome, had a good inhibition effect on tumor cells in urinary system. At the same time, Dauricine has certain inhibition effects on the primary cultured tumor cell.
目的
探讨三叶木通根茎提取物蝙蝠葛苏林碱对膀胱癌 EJ 细胞株、前列腺癌 PC-3M 细胞株及原代细胞培养系统的抗肿瘤作用。
方法
采用化学方法从三叶木通根茎中提取分离主要有效成分——酚性生物碱蝙蝠葛苏林碱。MTT 法检测蝙蝠葛苏林碱的抗肿瘤作用。
结果
蝙蝠葛苏林碱对泌尿系统主要肿瘤细胞具有明显的增殖抑制作用，最小药物敏感浓度在 3.81~5.15μg/ml 之间，且随着浓度的增加抑制率增加。
结论
从三叶木通根茎中提取的主要有效成分蝙蝠葛苏林碱对泌尿系统肿瘤细胞有较好的抑制作用。同时，蝙蝠葛苏林碱对原代培养的肿瘤细胞也有一定的抑制作用。
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