Xia Yong, Chen Ruijiao, Lu Guangzhen, Li Changlin, Lian Sen, Kang Taek-Won, Jung Young Do
Key Laboratory of Precision Oncology of Shandong Higher Education, Institute of Precision Medicine, Jining Medical University, Jining, China.
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Front Oncol. 2021 Apr 30;11:652033. doi: 10.3389/fonc.2021.652033. eCollection 2021.
Phytochemicals are natural small-molecule compounds derived from plants that have attracted attention for their anticancer activities. Some phytochemicals have been developed as first-line anticancer drugs, such as paclitaxel and vincristine. In addition, several phytochemicals show good tumor suppression functions in various cancer types. Bladder cancer is a malignant tumor of the urinary system. To date, few specific phytochemicals have been used for bladder cancer therapy, although many have been studied in bladder cancer cells and mouse models. Therefore, it is important to collate and summarize the available information on the role of phytochemicals in the prevention and treatment of bladder cancer. In this review, we summarize the effects of several phytochemicals including flavonoids, steroids, nitrogen compounds, and aromatic substances with anticancer properties and classify the mechanism of action of phytochemicals in bladder cancer. This review will contribute to facilitating the development of new anticancer drugs and strategies for the treatment of bladder cancer using phytochemicals.
植物化学物质是源自植物的天然小分子化合物，因其抗癌活性而备受关注。一些植物化学物质已被开发为一线抗癌药物，如紫杉醇和长春新碱。此外，几种植物化学物质在多种癌症类型中显示出良好的肿瘤抑制功能。膀胱癌是泌尿系统的恶性肿瘤。迄今为止，尽管许多植物化学物质已在膀胱癌细胞和小鼠模型中进行了研究，但用于膀胱癌治疗的特定植物化学物质很少。因此，整理和总结有关植物化学物质在膀胱癌预防和治疗中作用的现有信息非常重要。在本综述中，我们总结了几种具有抗癌特性的植物化学物质的作用，包括黄酮类、甾体类、含氮化合物和芳香物质，并对植物化学物质在膀胱癌中的作用机制进行了分类。本综述将有助于推动使用植物化学物质开发新的抗癌药物和治疗膀胱癌的策略。
