Cristóvão C, Cristóvão L, Nogueira F, Bicho M
Serviço de Pneumologia, Centro Hospitalar de Lisboa Ocidental, Hospital de Egas Moniz, Lisboa, Portugal.
Rev Port Pneumol. 2013 Mar-Apr;19(2):70-5. doi: 10.1016/j.rppneu.2012.09.002. Epub 2012 Nov 29.
Chronic Obstructive Pulmonary Disease (COPD) is one of the most common chronic diseases and a major cause of morbility and mortality. An imbalance between oxidants and antioxidants (oxidative stress) has been proposed as a critical event in the pathogenesis of COPD. The increased oxidative stress in patients with COPD is the result of exogenous oxidants namely pollutants and cigarette smoke as well as endogenous oxidant production during inflammation. The aim of the present study was to clarify the hypothesis about the presence of an imbalance between oxidants and the antioxidant defences associated to COPD. In this study, we evaluated a biomarker of oxidative stress (malondialdehyde, a lipid peroxidation derived product) and non-enzymatic antioxidants (vitamin C and the sulphydryl groups) in COPD patients and healthy controls. The marker of oxidative stress was found to be significantly (p<0,001) higher in COPD patients when compared with the control group. No age dependent changes in the plasma levels of lipid peroxidation products were found. COPD patients had a significant (p<0,001) decrease in antioxidant status compared with control group. Our results show that oxidative stress is an important pathophysiologic change in COPD.
慢性阻塞性肺疾病（COPD）是最常见的慢性疾病之一，也是发病和死亡的主要原因。氧化剂与抗氧化剂之间的失衡（氧化应激）被认为是COPD发病机制中的关键事件。COPD患者氧化应激增加是外源性氧化剂（即污染物和香烟烟雾）以及炎症期间内源性氧化剂产生的结果。本研究的目的是阐明关于COPD相关的氧化剂与抗氧化防御之间存在失衡这一假说。在本研究中，我们评估了COPD患者和健康对照者氧化应激的生物标志物（丙二醛，一种脂质过氧化衍生产物）和非酶抗氧化剂（维生素C和巯基）。与对照组相比，COPD患者的氧化应激标志物显著更高（p<0.001）。未发现脂质过氧化产物血浆水平存在年龄依赖性变化。与对照组相比，COPD患者的抗氧化状态显著降低（p<0.001）。我们的结果表明，氧化应激是COPD重要的病理生理变化。
