Pandey Sarika, Garg Rajiv, Kant Surya, Gaur Priyanka
Department of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.
Department of Physiology, King George's Medical University, Lucknow, Uttar Pradesh, India.
Tzu Chi Med J. 2019 Dec 5;33(1):80-86. doi: 10.4103/tcmj.tcmj_198_19. eCollection 2021 Jan-Mar.
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Systemic inflammation and oxidant/antioxidant imbalance has been seen to play a key role in pathogenesis of COPD. The present study investigated the levels of inflammatory and antioxidant/oxidative stress biomarker in COPD patients and healthy subjects.
The present study enrolled seventy COPD patients and seventy healthy controls from Department of Respiratory Medicine at a tertiary care hospital. Vitamin D, C-reactive protein (CRP), superoxide dismutase (SOD), catalase, and malondialdehyde (MDA) levels were measured in both cases and control. GraphPad PRISM version 6.01 was used for analysis of data.
The levels of Vitamin D, SOD, Catalase, were found to be significantly lower among the COPD patients in comparison to healthy controls while levels of MDA and CRP were significantly higher ( = 0.0001).
The results showed oxidant/antioxidant imbalance and Vitamin D deficiency in COPD patients. Higher levels of CRP and oxidative stress markers were observed in COPD patients in comparison to healthy controls. A biomarker based study testing the efficacy of novel antioxidant or other agents will be helpful that can modify the course of this disease.
慢性阻塞性肺疾病（COPD）是全球发病率和死亡率的主要原因。全身炎症以及氧化/抗氧化失衡在COPD发病机制中起关键作用。本研究调查了COPD患者和健康受试者体内炎症及抗氧化/氧化应激生物标志物的水平。
本研究纳入了一家三级护理医院呼吸内科的70例COPD患者和70名健康对照者。对病例组和对照组均检测了维生素D、C反应蛋白（CRP）、超氧化物歧化酶（SOD）、过氧化氢酶和丙二醛（MDA）水平。使用GraphPad PRISM 6.01版进行数据分析。
与健康对照者相比，COPD患者的维生素D、SOD、过氧化氢酶水平显著降低，而MDA和CRP水平显著升高（P = 0.0001）。
结果显示COPD患者存在氧化/抗氧化失衡和维生素D缺乏。与健康对照者相比，COPD患者的CRP和氧化应激标志物水平更高。一项基于生物标志物的研究，测试新型抗氧化剂或其他药物的疗效，将有助于改变这种疾病的病程。
