De Stefano Alessandro, Dispenza Francesco, Petrucci Anna Grazia, Citraro Leonardo, Croce Adelchi
ENT Institute, Department of Oral and Nano-Biotechnological Sciences, G d'Annunzio University of Chieti and Pescara, Italy.
Otolaryngol Pol. 2012 Nov-Dec;66(6):419-23. doi: 10.1016/j.otpol.2012.06.002. Epub 2012 Jun 6.
Metatypical Basal Cell Carcinoma, also known as Basosquamous Carcinoma is a subtype of Basal Cell Carcinoma. It is similar to Basal Cell Carcinoma for the gross aspect and regional recurrences, but it has the capacity to spread and develop metastasis. This terrible characteristic endangers the life of the patient if it is not readily recognized by the physicians. Herein we present a report of two patients affected by BSC originating in the nasal region and external ear that after a series of devastating local recurrences metastasized to the lung and bones in one case. The true incidence of Basoquamous Carcinoma may be higher, with underreporting arising because of rarity of diagnosis and lack of awareness on the part of clinicians. Our experience suggests that a deep biopsy is often necessary to discover a BSC that appears as BCC but with local aggressive features.
异型基底细胞癌，也称为基底鳞状细胞癌，是基底细胞癌的一种亚型。在大体外观和局部复发方面，它与基底细胞癌相似，但它有扩散和发生转移的能力。如果医生不能及时识别，这种可怕的特征会危及患者的生命。在此，我们报告两例起源于鼻区和外耳道的基底鳞状细胞癌患者，其中一例在经历一系列破坏性的局部复发后转移至肺和骨。基底鳞状细胞癌的实际发病率可能更高，由于诊断罕见以及临床医生认识不足，导致报告不充分。我们的经验表明，对于看似基底细胞癌但具有局部侵袭性特征的基底鳞状细胞癌，通常需要进行深部活检才能发现。
