Department of Microbiology and Molecular Biology, Brigham Young University, 857 WIDB, Provo, UT 84602, USA.
Clin Immunol. 2013 Sep;148(3):335-43. doi: 10.1016/j.clim.2012.11.001. Epub 2012 Nov 12.
Cytokines regulate and control the immune system. In systemic lupus erythematosus, several of these cytokines are overexpressed and contribute to the pathogenesis of the disease. Cytokine inhibition has been successfully used to treat other rheumatic and autoimmune diseases, and several cytokines are currently being investigated to determine whether inhibition would be therapeutic in lupus. The cytokines discussed in this review have all undergone clinical trials, and include TNF-α, IL-1, IL-6, IL-10, IL-15, IL-17, IL-18 and IL-23. Inhibition of the majority of these targets was safe and showed some efficacy in treating lupus. Cytokine inhibition strategies have just started to realize their potential for the treatment of this difficult disease, and show great promise for the future.
细胞因子调节和控制免疫系统。在系统性红斑狼疮中，其中一些细胞因子过度表达，导致疾病的发病机制。细胞因子抑制已成功用于治疗其他风湿和自身免疫性疾病，目前正在研究几种细胞因子，以确定抑制是否对狼疮具有治疗作用。本综述中讨论的细胞因子均已进行临床试验，包括 TNF-α、IL-1、IL-6、IL-10、IL-15、IL-17、IL-18 和 IL-23。抑制这些靶点中的大多数都是安全的，并在治疗狼疮方面显示出一定的疗效。细胞因子抑制策略才刚刚开始发挥其治疗这种难治性疾病的潜力，为未来带来了巨大的希望。
