细胞之旅：mRNA 的运输与锚定。
Taking a cellular road-trip: mRNA transport and anchoring.
机构信息
Department of Molecular Biology, Cell Biology & Biochemistry, Brown University, Providence, RI, USA.
出版信息
Curr Opin Cell Biol. 2013 Feb;25(1):99-106. doi: 10.1016/j.ceb.2012.08.015. Epub 2012 Nov 30.
Abstract
mRNA localization is a crucial mechanism for post-transcriptional control of gene expression used in numerous cellular contexts to generate asymmetric enrichment of an encoded protein. This process has emerged as a fundamental regulatory mechanism that operates in a wide range of organisms to control an array of cellular processes. Recently, significant advances have been made in our understanding of the mechanisms that regulate several steps in the mRNA localization pathway. Here we discuss the progress made in understanding localization element recognition, paying particular attention to the role of RNA structure. We also consider the function of mRNP granules in mRNA transport, as well as new results pointing to roles for the endocytic pathway in mRNA localization.
摘要
mRNA 定位是一种在后转录水平控制基因表达的关键机制，在许多细胞环境中被用来产生编码蛋白的不对称富集。这一过程已成为一种基本的调节机制，在广泛的生物体中控制着一系列的细胞过程。最近，我们在理解调节 mRNA 定位途径中几个步骤的机制方面取得了重大进展。在这里，我们讨论了在理解定位元件识别方面取得的进展，特别关注 RNA 结构的作用。我们还考虑了 mRNP 颗粒在 mRNA 运输中的功能，以及新的结果表明内吞途径在 mRNA 定位中的作用。
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