Laboratory for Cognitive Neurology, KU Leuven, Belgium.
Neuroimage. 2013 Feb 15;67:257-72. doi: 10.1016/j.neuroimage.2012.11.026. Epub 2012 Nov 29.
Selection and reorienting are two fundamental aspects of spatial attention. By means of event-related fMRI in a total of 26 subjects, we localized these two processes within a same experiment applying a probabilistic cytoarchitectonic reference frame. In a classical spatial cueing paradigm, the target was presented at the cued location either alone (60% of trials) or in combination with a contralateral distracter ('competition trials', 20% of trials), or at a location opposite to the cued location ('invalidly cued trials', 20% of trials). In a sensory control experiment we differentiated between the attentional and the sensory effects of the distracter. In areas hIP1 and hIP3, competition trials exerted a significantly stronger attentional effect than invalidity trials. Conversely, area PF in the right hemisphere showed an invalidity effect in the absence of competition effect. A third type of response was found in areas PFm and PGa which showed both an invalidity and a competition effect. The combined study of selection and reorienting using a cytoarchitectonic reference frame enabled us to resolve the wide between-study variance in temporoparietal coordinates associated with the invalidity effect. Furthermore, the study demonstrated within a same experiment a functional dissociation between reorienting and selection in parietal cortex.
选择和重新定向是空间注意的两个基本方面。通过在总共 26 名受试者中进行事件相关 fMRI，我们在同一个实验中应用概率细胞构筑参考框架定位了这两个过程。在经典的空间提示范式中，目标要么单独出现在提示位置（60%的试验），要么与对侧干扰物一起出现（“竞争试验”，20%的试验），要么出现在与提示位置相对的位置（“无效提示试验”，20%的试验）。在感觉控制实验中，我们区分了干扰物的注意力和感觉效应。在 hIP1 和 hIP3 区域，竞争试验比无效性试验产生了更强的注意力效应。相反，在右侧半球的 PF 区域在没有竞争效应的情况下表现出无效性效应。在 PFm 和 PGa 区域发现了第三种反应，它们同时表现出无效性和竞争性效应。使用细胞构筑参考框架对选择和重新定向进行联合研究，使我们能够解决与无效性效应相关的 temporoparietal 坐标在研究之间的广泛差异。此外，该研究在同一个实验中证明了顶叶皮层中重新定向和选择之间的功能分离。
