Lu Zhuo, Huang Yufeng, Lu Qilin, Feng Lixia, Nguchu Benedictor Alexander, Wang Yanming, Wang Huijuan, Li Geng, Zhou Yifeng, Qiu Bensheng, Zhou Jiawei, Wang Xiaoxiao
1Center for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui 230027 People's Republic of China.
2Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Science, University of Science and Technology of China, Hefei, Anhui 230027 People's Republic of China.
Eye Vis (Lond). 2019 Jul 9;6:20. doi: 10.1186/s40662-019-0145-2. eCollection 2019.
Amblyopia (lazy eye) is one of the most common causes of monocular visual impairment. Intensive investigation has shown that amblyopes suffer from a range of deficits not only in the primary visual cortex but also the extra-striate visual cortex. However, amblyopic brain processing deficits in large-scale information networks especially in the visual network remain unclear.
Through resting state functional magnetic resonance imaging (rs-fMRI), we studied the functional connectivity and efficiency of the brain visual processing networks in 18 anisometropic amblyopic patients and 18 healthy controls (HCs).
We found a loss of functional correlation within the higher visual network (HVN) and the visuospatial network (VSN) in amblyopes. Additionally, compared with HCs, amblyopic patients exhibited disruptions in local efficiency in the V3v (third visual cortex, ventral part) and V4 (fourth visual cortex) of the HVN, as well as in the PFt, hIP3 (human intraparietal area 3), and BA7p (Brodmann area 7 posterior) of the VSN. No significant alterations were found in the primary visual network (PVN).
Our results indicate that amblyopia results in an intrinsic decrease of both network functional correlations and local efficiencies in the extra-striate visual networks.
弱视（懒眼症）是单眼视力损害最常见的原因之一。深入研究表明，弱视患者不仅在初级视觉皮层，而且在纹外视觉皮层都存在一系列缺陷。然而，弱视患者在大规模信息网络尤其是视觉网络中的脑处理缺陷仍不清楚。
通过静息态功能磁共振成像（rs-fMRI），我们研究了18例屈光参差性弱视患者和18例健康对照者（HCs）脑视觉处理网络的功能连接性和效率。
我们发现弱视患者的高级视觉网络（HVN）和视觉空间网络（VSN）内功能相关性丧失。此外，与HCs相比，弱视患者在HVN的V3v（第三视觉皮层，腹侧部分）和V4（第四视觉皮层）以及VSN的PFt、hIP3（人类顶内沟区3）和BA7p（布罗德曼区7后部）的局部效率受到破坏。在初级视觉网络（PVN）中未发现显著改变。
我们的结果表明，弱视导致纹外视觉网络中网络功能相关性和局部效率的内在降低。
