Storr Liver Unit, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Australia.
Cancer Lett. 2013 Mar 1;330(1):1-10. doi: 10.1016/j.canlet.2012.11.038. Epub 2012 Nov 29.
There is emerging evidence that the association between obesity and cancer is mediated by visceral rather than generalised body fat. Visceral fat has been directly implicated in the risk and progression of several gastrointestinal cancers including colorectal, oesophageal, pancreatic and hepatocellular carcinomas. Excess visceral adipose tissue induces a state of chronic systemic inflammation and altered metabolic activity that promotes a pro-oncogenic environment. This review examines the evidence linking visceral fat in gastrointestinal and hepatic carcinogenesis and explores our current understanding of the mechanisms underlying this relationship.
越来越多的证据表明，肥胖与癌症之间的关联是由内脏脂肪而不是全身性脂肪引起的。内脏脂肪直接参与了几种胃肠道癌症（包括结直肠癌、食管癌、胰腺癌和肝细胞癌）的风险和进展。过多的内脏脂肪组织会引起慢性全身性炎症和代谢活性改变，从而促进致癌环境的形成。本文综述了内脏脂肪与胃肠道和肝脏发生癌变之间的关联，并探讨了我们目前对这种关系背后机制的理解。
