Department of Community Medicine, University of Tromso, NO-9037 Tromso, Norway.
Environ Int. 2013 Jan;51:82-7. doi: 10.1016/j.envint.2012.10.008. Epub 2012 Nov 28.
Dermal application of personal care products (PCPs) is considered an important human exposure route for siloxanes. Their presence as minor or major constituents in many personal care products (PCPs) and cosmetics is of concern for human exposure. The aim of this study was to quantify cyclic volatile methylsiloxanes (cVMS) in blood plasma of pregnant and postmenopausal women, and to investigate possible links to self-reported use of PCPs for the latter group. Participants were recruited from two studies, namely the Norwegian Women and Cancer Study (NOWAC) and the North Norwegian Mother-and-child Study (MISA). For the NOWAC cohort, 94 plasma samples from postmenopausal women were analyzed (blood drawn in 2005) and information about PCP use and breast implants was derived from a self-administered questionnaire. In the MISA study, the collection of the plasma samples (blood drawn in 2009) constituted a re-sampling because the original serum vacutainers used were contaminated with cVMS. D4 (octamethylcyclotetrasiloxane) was the dominant compound in plasma for both cohorts. For the NOWAC samples, more than 85% of the women had D4 concentrations above the LOQ (2.74 ng/mL), while the detection frequency was only 18% for the MISA participants. The highest cVMS plasma concentrations were observed for D4: 12.7 ng/mL (NOWAC) and 2.69 ng/mL (MISA). For the other cVMS, decamethylcyclopentasiloxane (D5) and dodecamethylcyclohexasiloxane (D6) concentrations were below the detection limit in most samples. There was no significant correlation between the concentrations of D4 and the reported total body cream use. Sampling time (2005 versus 2009) and age of the donors could explain the differences between the two cohorts.
皮肤涂抹个人护理产品（PCP）被认为是硅氧烷进入人体的重要途径。硅氧烷作为许多个人护理产品（PCP）和化妆品的少量或主要成分，引起了人们对人类接触的关注。本研究的目的是定量检测孕妇和绝经后妇女血浆中环状挥发性甲基硅氧烷（cVMS）的含量，并调查后者群体自我报告使用 PCP 的可能联系。参与者是从两项研究中招募的，即挪威妇女与癌症研究（NOWAC）和北挪威母婴研究（MISA）。对于 NOWAC 队列，分析了 94 名绝经后妇女的 94 份血浆样本（2005 年采血），并从自我管理的问卷中获得了关于 PCP 使用和乳房植入物的信息。在 MISA 研究中，由于原始血清真空采血管受到 cVMS 污染，因此重新采集了血浆样本（2009 年采血）。对于两个队列，D4（八甲基环四硅氧烷）都是血浆中的主要化合物。对于 NOWAC 样本，超过 85%的女性 D4 浓度高于 LOQ（2.74ng/ml），而 MISA 参与者的检测频率仅为 18%。D4 的最高 cVMS 血浆浓度为 12.7ng/ml（NOWAC）和 2.69ng/ml（MISA）。对于其他的 cVMS，十甲基环五硅氧烷（D5）和十二甲基环己硅氧烷（D6）的浓度在大多数样本中低于检测限。D4 浓度与报告的全身乳膏使用量之间没有显著相关性。采样时间（2005 年与 2009 年）和供体年龄可以解释两个队列之间的差异。
