Harley Leyenda, Langston Cathy
New Haven Central Hospital for Veterinary Medicine, 843 State Street, New Haven, CT 06511, USA.
Can Vet J. 2012 Jun;53(6):631-8.
Proteinuria is defined as the presence of protein in the urine. Normally, circulating serum proteins are blocked by the glomerulus due to size and/or charge. Any small proteins that pass through a healthy glomerulus are reabsorbed by the renal tubules or broken down by renal tubular epithelial cells. Persistent proteinuria, in the absence of lower urinary tract disease or reproductive tract disease, is usually an indication of renal damage or dysfunction. Less commonly persistent proteinuria can be caused by increased circulating levels of low molecular weight proteins. This article reviews mechanisms of proteinuria in dogs and cats and discusses the importance of screening for and ultimately treating proteinuria.
蛋白尿的定义为尿液中存在蛋白质。正常情况下，循环血清蛋白因大小和/或电荷被肾小球阻挡。任何通过健康肾小球的小分子蛋白质会被肾小管重吸收或被肾小管上皮细胞分解。在没有下尿路疾病或生殖道疾病的情况下，持续性蛋白尿通常表明肾脏受损或功能障碍。持续性蛋白尿较少见的原因可能是循环中低分子量蛋白质水平升高。本文综述了犬猫蛋白尿的机制，并讨论了筛查及最终治疗蛋白尿的重要性。
