Kovarikova Simona, Blahova Jana, Steffenova Veronika, Vaskova Natalie, Jahn Petr
Department of Animal Protection and Welfare and Veterinary Public Health, Faculty of Veterinary Hygiene and Ecology, University of Veterinary Sciences, 61242 Brno, Czech Republic.
Equine Clinic, Faculty of Veterinary Medicine, University of Veterinary Sciences, 61242 Brno, Czech Republic.
Vet Sci. 2025 Aug 21;12(8):783. doi: 10.3390/vetsci12080783.
Currently, there is relatively little published information on the urine protein-to-creatinine (UPC) ratio in horses, a parameter commonly used in dogs and cats. The aim of this study was to determine the reference range of UPC in urine samples of apparently healthy horses and to assess the influence of age and sex. Urinalysis and the determination of urinary protein and creatinine concentrations and ratios were performed. A total of 118 urine samples from apparently healthy horses were included in the study: 10 from foals younger than 6 months and 108 from horses older than 1 year. The median UPC for foals younger than 6 months and horses aged 1-4 years, 5-10 years, 11-17 years and older than 18 years were 0.074, 0.073, 0.070, 0.083, and 0.070, respectively. Using the non-parametric Kruskal-Wallis test, statistically significant differences were found between the youngest age group and both groups of adult horses (i.e., 5-10 years and 11-17 years); however, these differences were not confirmed by the General Linear Model, likely due to the small sample sizes in some categories. There was no effect of sex on UPC. The indicative reference range was set for the group of horses aged 5-17 years as 0.02-0.18.
目前，关于马的尿蛋白与肌酐（UPC）比值的已发表信息相对较少，该参数常用于犬猫。本研究的目的是确定明显健康马匹尿液样本中UPC的参考范围，并评估年龄和性别的影响。进行了尿液分析以及尿蛋白和肌酐浓度及比值的测定。共有118份来自明显健康马匹的尿液样本纳入研究：10份来自6个月以下的幼驹，108份来自1岁以上的马匹。6个月以下幼驹以及1 - 4岁、5 - 10岁、11 - 17岁和18岁以上马匹的UPC中位数分别为0.074、0.073、0.070、0.083和0.070。使用非参数Kruskal - Wallis检验，在最年轻年龄组与两组成年马（即5 - 10岁和11 - 17岁）之间发现了统计学上的显著差异；然而，这些差异未得到一般线性模型的证实，可能是由于某些类别中的样本量较小。性别对UPC没有影响。5 - 17岁马匹组的指示性参考范围设定为0.02 - 0.18。
