Manivelavan D, C K Vijayasamundeeswari
Assistant Professor of Orthopaedics, Vinayaka Mission's Kirupananda Variyar Medical College and Hospital , Salem,Tamilnadu,India.
J Clin Diagn Res. 2012 Oct;6(8):1393-6. doi: 10.7860/JCDR/2012/4692.2367.
To evaluate the role of Anti-Cyclic Citrullinated Peptide (anti-CCP) antibody and Rheumatoid Factor (RF) in Rheumatoid Arthritis (RA) patients.
The present study comprised of 60 clinically diagnosed rheumatoid arthritis patients and 30 apparently healthy subjects as controls. Among 60 RA patients, 30 were <2 years duration and 30 were 3 to 15 years duration. Anti-CCP and RF levels were analyed by ELISA and immunoturbidimetric assay respectively. Disease activity was assessed by disease duration, duration of morning stiffness, hand deformity and radiological findings. Anti-CCP and rheumatoid factor were measured.
A valid comparison showed that autoantibodies directed to citrullinated antigen-anti-CCP are superior to RF for the detection of RA. Anti-CCP antibodies have an independent role in predicting radiological damage and progression in RA patients.
With their excellent specificity, anti-CCP antibodies can be used as serological marker in establishing the diagnosis of RA. Anti-CCP antibodies discriminated accurately between erosive and nonerosive RA making them a potentially good prognostic marker for the disease.
评估抗环瓜氨酸肽（anti-CCP）抗体和类风湿因子（RF）在类风湿关节炎（RA）患者中的作用。
本研究包括60例临床诊断为类风湿关节炎的患者和30例明显健康的受试者作为对照。在60例RA患者中，30例病程小于2年，30例病程为3至15年。分别采用酶联免疫吸附测定（ELISA）和免疫比浊法分析抗CCP和RF水平。通过疾病持续时间、晨僵持续时间、手部畸形和影像学检查结果评估疾病活动度。检测抗CCP和类风湿因子。
有效比较表明，针对瓜氨酸化抗原的自身抗体——抗CCP在检测RA方面优于RF。抗CCP抗体在预测RA患者的影像学损伤和病情进展方面具有独立作用。
抗CCP抗体具有出色的特异性，可作为确立RA诊断的血清学标志物。抗CCP抗体能准确区分侵蚀性和非侵蚀性RA，使其成为该疾病潜在的良好预后标志物。
