Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
J Bacteriol. 2012 Dec;194(24):6988-9. doi: 10.1128/JB.01916-12.
Streptomyces sp. SS produces a series of uridyl peptide antibiotic sansanmycins. Here, we present a draft genome sequence of Streptomyces sp. SS containing the biosynthetic gene cluster for the antibiotics. The identification of the biosynthetic gene cluster of sansanmycins may provide further insight into biosynthetic mechanisms for uridyl peptide antibiotics.
链霉菌 SS 产生了一系列尿嘧啶肽抗生素三杉霉素。在这里,我们呈现了链霉菌 SS 的基因组草图序列,其中包含了抗生素的生物合成基因簇。三杉霉素生物合成基因簇的鉴定可能为尿嘧啶肽抗生素的生物合成机制提供进一步的认识。