Allergology and Immunology Unit, Niguarda Ca' Granda Hospital, 20162 Milan, Italy.
J Agric Food Chem. 2013 Jan 23;61(3):740-6. doi: 10.1021/jf303291k. Epub 2013 Jan 14.
Fennel allergy has been rarely reported, and the association with peach allergy has never been described. Our aim was to (i) study the correlation between symptom severity of peach and fennel and (ii) identify fennel allergens and the role of rPru p 3 antibodies in severe reactions to fennel. In 148 patients with peach allergy, we investigated 58 patients with symptoms and IgE antibodies positive to fennel. IgE to rPru p 1, 3, and 4 and rBet v 1, 2, and 4 were measured by immunoblotting, and the N-terminal amino acid sequences and relevant allergens were determined. We found significant association between severe reactions to fennel and peach (p = 0.0009). A major allergen was ~9 kDa lipid-transfer protein (LTP), cross-reactive with Pru p 3, a 15 kDa protein identified as a pathogenesis-related protein 1 of the Bet v 1 family. In conclusion, peach and fennel severe allergic symptoms are significantly related, and LTP is a major fennel allergen. Fennel should be included in the LTP syndrome.
茴香过敏很少见，与桃过敏的相关性从未被描述过。我们的目的是：（i）研究桃和茴香过敏症状严重程度之间的相关性；（ii）鉴定茴香过敏原和 rPru p 3 抗体在严重茴香过敏反应中的作用。在 148 例桃过敏患者中，我们调查了 58 例对茴香有症状和 IgE 抗体阳性的患者。通过免疫印迹法测量了 rPru p 1、3 和 4 以及 rBet v 1、2 和 4 的 IgE，确定了 N-末端氨基酸序列和相关过敏原。我们发现茴香和桃严重过敏反应之间存在显著关联（p = 0.0009）。一种主要过敏原是约 9 kDa 的脂质转移蛋白（LTP），与 Pru p 3 发生交叉反应，Pru p 3 是 Bet v 1 家族的一种 15 kDa 蛋白，被鉴定为一种与发病机制相关的蛋白 1。总之，桃和茴香的严重过敏症状有显著相关性，LTP 是一种主要的茴香过敏原。茴香应包括在 LTP 综合征中。
