Uasuf Carina Gabriela, Villalta Danilo, Conte Maria Elisabetta, Di Sano Caterina, Barrale Maria, Cantisano Vincenzo, Pace Elisabetta, Gjomarkaj Mark, Gangemi Sebastiano, Brusca Ignazio
Allergy Diseases Center "Prof. G. Bonsignore", Institute of Biomedicine and Molecular Immunology "A. Monroy"(IBIM)-National Research Council (CNR), Palermo, Italy.
Allergy and Clinical Immunology Unit, A.O "S. Maria degli Angeli di Pordenone", Pordenone, Italy.
Clin Mol Allergy. 2015 Dec 2;13:30. doi: 10.1186/s12948-015-0035-7. eCollection 2015.
In Italy, the nsLTP (Pru p 3) has been identified as the most frequent cause of food allergy and anaphylaxis. In order to estimate the risk assessment in peach allergy, we investigated the presence of correlations between the levels of sIgE to Pru p 3 with the severity of the clinical symptoms in two Pru p 3 positive populations from two different areas of Italy.
133 consecutively Pru p 3 positive patients were recruited from South Italy, where the prevalence of PR-10 and profilin sensitization is low, and from North-East Italy, where the sensitization to pathogenesis related protein -10 (PR-10) and profilin is higher. Skin prick test (SPT) to peach extract and sIgE to peach panallergens were performed.
All 133 patients were positive to SPT to peach extract and to sIgE to Pru p 3. The North-East population was simultaneously positive to Pru p 1 (42.8 %) and Pru p 4 (12.7 %), while no Southern patients were positive to PR-10 or to profilin. A significant difference in the levels of sIgE to Pru p 3 was found only in South Italy Pru p 3 + patients vs. asymptomatic patients (p = 0.01) and in mild reactions vs. severe reactions (p = 0.0008). In South Italy patients, it was also found a significant correlation between the severity of the clinical reaction and the levels of sIgE to Pru p 3 (p = 0.001).
Level of sIgE to Pru p 3 indicates the possibility of development a severe food allergic reaction. Pru p 3 positive patients from different geographical areas and with different co-sensitizations to Pru p 1 and/or Pru p 4 could have a different risk assessment in peach allergy.
在意大利，非特异性脂质转移蛋白（Pru p 3）已被确定为食物过敏和过敏反应最常见的原因。为了评估桃子过敏的风险，我们调查了来自意大利两个不同地区的两个Pru p 3阳性人群中，sIgE对Pru p 3的水平与临床症状严重程度之间的相关性。
从意大利南部招募了133例连续的Pru p 3阳性患者，该地区PR-10和肌动蛋白结合蛋白致敏率较低；从意大利东北部招募了患者，该地区对致病相关蛋白-10（PR-10）和肌动蛋白结合蛋白的致敏率较高。对桃子提取物进行皮肤点刺试验（SPT），并检测对桃子全过敏原的sIgE。
所有133例患者对桃子提取物的SPT和对Pru p 3的sIgE均呈阳性。东北部人群同时对Pru p 1（42.8%）和Pru p 4（12.7%）呈阳性，而南部患者对PR-10或肌动蛋白结合蛋白均无阳性反应。仅在意大利南部Pru p 3 +患者与无症状患者之间（p = 0.01）以及轻度反应与重度反应之间（p = 0.0008），发现sIgE对Pru p 3的水平存在显著差异。在意大利南部患者中，还发现临床反应的严重程度与sIgE对Pru p 3的水平之间存在显著相关性（p = 0.001）。
sIgE对Pru p 3的水平表明发生严重食物过敏反应的可能性。来自不同地理区域且对Pru p 1和/或Pru p 4有不同共致敏情况的Pru p 3阳性患者在桃子过敏方面可能有不同的风险评估。
