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The interfaces between signal transduction pathways: IGF-1/mTor, p53 and the Parkinson Disease pathway.

作者信息

Levine Arnold J, Harris Chris R, Puzio-Kuter Anna M

机构信息

Cancer Institute of New Jersey, UMDNJ, New Brunswick, NJ, USA.

出版信息

Oncotarget. 2012 Nov;3(11):1301-7. doi: 10.18632/oncotarget.759.

DOI:10.18632/oncotarget.759
PMID:23211569
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3717794/
Abstract
摘要

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The Regulation of Multiple p53 Stress Responses is Mediated through MDM2.多种p53应激反应的调节是通过MDM2介导的。
Genes Cancer. 2012 Mar;3(3-4):199-208. doi: 10.1177/1947601912454734.
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Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice.雷帕霉素可延长杂合型p53+/-小鼠的寿命并延缓其肿瘤发生。
Aging (Albany NY). 2012 Oct;4(10):709-14. doi: 10.18632/aging.100498.
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New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis.雷帕霉素的新型纳米制剂Rapatar通过延缓致癌作用延长纯合p53基因敲除小鼠的寿命。
Mol Neurobiol. 2018 Jan;55(1):506-516. doi: 10.1007/s12035-016-0303-7. Epub 2016 Dec 14.
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cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response.cMyc-p53反馈机制调节免疫反应中T淋巴细胞的动态变化。
Cell Cycle. 2016 May 2;15(9):1267-75. doi: 10.1080/15384101.2016.1160975.
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Quantitative analysis of male germline stem cell differentiation reveals a role for the p53-mTORC1 pathway in spermatogonial maintenance.雄性生殖系干细胞分化的定量分析揭示了p53-mTORC1信号通路在精原细胞维持中的作用。
Cell Cycle. 2015;14(18):2905-13. doi: 10.1080/15384101.2015.1069928.
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Gerosuppression in confluent cells.汇合细胞中的衰老抑制。
Aging (Albany NY). 2014 Dec;6(12):1010-8. doi: 10.18632/aging.100714.
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Oncotarget. 2014 Nov 15;5(21):10382-92. doi: 10.18632/oncotarget.2060.
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Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3.二氯乙酸钠在B细胞慢性淋巴细胞白血病（B-CLL）中表现出抗白血病活性，并与p53激活剂Nutlin-3协同作用。
Oncotarget. 2014 Jun 30;5(12):4347-60. doi: 10.18632/oncotarget.2018.
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PLoS One. 2012;7(3):e32503. doi: 10.1371/journal.pone.0032503. Epub 2012 Mar 19.
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p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2.p53 负调控丙酮酸脱氢酶激酶 Pdk2 的转录。
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Redox regulation of p53, redox effectors regulated by p53: a subtle balance.p53 的氧化还原调控，p53 调控的氧化还原效应物：微妙的平衡。
Antioxid Redox Signal. 2012 Jun 1;16(11):1285-94. doi: 10.1089/ars.2011.4434. Epub 2012 Jan 25.