信号转导通路之间的界面：胰岛素样生长因子-1/雷帕霉素靶蛋白、p53与帕金森病通路。 - Suppr

Suppr

超能文献

The interfaces between signal transduction pathways: IGF-1/mTor, p53 and the Parkinson Disease pathway.

作者信息

Levine Arnold J, Harris Chris R, Puzio-Kuter Anna M

机构信息

Cancer Institute of New Jersey, UMDNJ, New Brunswick, NJ, USA.

出版信息

Oncotarget. 2012 Nov;3(11):1301-7. doi: 10.18632/oncotarget.759.

DOI:10.18632/oncotarget.759

PMID:23211569

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3717794/

Abstract

摘要

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Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice.雷帕霉素可延长杂合型p53+/-小鼠的寿命并延缓其肿瘤发生。

Aging (Albany NY). 2012 Oct;4(10):709-14. doi: 10.18632/aging.100498.

New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis.雷帕霉素的新型纳米制剂Rapatar通过延缓致癌作用延长纯合p53基因敲除小鼠的寿命。

Aging (Albany NY). 2012 Oct;4(10):715-22. doi: 10.18632/aging.100496.

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