Institute of Medical Biology, 8A Biomedical Grove, Immunos 06-06, Singapore 138648. Brian.Burke@ imb.a-star.edu.sg
Nat Rev Mol Cell Biol. 2013 Jan;14(1):13-24. doi: 10.1038/nrm3488. Epub 2012 Dec 5.
The nuclear lamina is an important structural determinant for the nuclear envelope as a whole, attaching chromatin domains to the nuclear periphery and localizing some nuclear envelope proteins. The major components of the lamina are the A-type and B-type lamins, which are members of the intermediate filament protein family. Whereas the expression of A-type lamins is developmentally regulated, B-type lamins, as a class, are found in all cells. The association of B-type lamins with many aspects of nuclear function has led to the view that these are essential proteins, and there is growing evidence suggesting that they regulate cellular senescence. However, B-type lamins are dispensable in certain cell types in vivo, and neither A-type nor B-type lamins may be required in early embryos or embryonic stem cells. The picture that is beginning to emerge is of a complex network of interactions at the nuclear periphery that may be defined by cell- and tissue-specific functions.
核纤层是核膜作为一个整体的重要结构决定因素，它将染色质域附着到核周边，并将一些核膜蛋白定位在那里。核纤层的主要成分是 A 型和 B 型核纤层蛋白，它们是中间丝蛋白家族的成员。虽然 A 型核纤层蛋白的表达受到发育调控，但 B 型核纤层蛋白作为一类存在于所有细胞中。B 型核纤层蛋白与核功能的许多方面有关，这导致人们认为它们是必需的蛋白质，并且越来越多的证据表明它们调节细胞衰老。然而，B 型核纤层蛋白在体内某些细胞类型中是可有可无的，并且在早期胚胎或胚胎干细胞中可能不需要 A 型或 B 型核纤层蛋白。目前出现的情况是，核周边的相互作用网络可能由细胞和组织特异性功能定义。
