Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Gastroenterol Res Pract. 2012;2012:671927. doi: 10.1155/2012/671927. Epub 2012 Nov 19.
Introduction. The pathogenicity and transmission routes of Transfusion Transmitted Virus (TTV) remain unclear. The aim of this study was to determine the prevalence of TTV in hemodialysis patients, injecting drug users (IDUs), and healthy blood donors, in Isfahan, Iran. Method. In a case-control study, a total of 108 subjects were put into three groups namely Group I, 36 hemodialysis patients; Group II, 36 IDUs; and Group III, 36 healthy blood donors as the control group. A 5 ml blood sample was collected from each subject in an EDTA-containing tube. Samples were tested for TTV DNA by means of real-time polymerase chain reaction (PCR). Results. The mean age was 38.7 ± 14.7 years. Seventy-one subjects (66%) were male. Of the108 cases, 30 (27.8%) were TTV positive and 78 (72.2%) were TTV negative. The prevalence of TTV in IDUs [21 (58%)] was significantly higher than in the other groups [group I: 6 (17 %) and group III: 3 (8%)] (P < 0.0001). Conclusion. The prevalence of TTV in IDUs is significantly higher than in both hemodialysis patients and general population in Isfahan, Iran. It seems necessary to take serious measures to reduce the risk of TTV transmission to IDUs' close contacts and health care providers.
介绍。输血传播病毒（TTV）的致病性和传播途径仍不清楚。本研究的目的是确定输血传播病毒在伊朗伊斯法罕的血液透析患者、静脉注射吸毒者（IDUs）和健康献血者中的流行率。方法。在一项病例对照研究中，共有 108 名受试者分为三组：第 I 组 36 名血液透析患者；第 II 组 36 名 IDUs；第 III 组 36 名健康献血者作为对照组。从每个研究对象的 EDTA 管中采集 5ml 血样。采用实时聚合酶链反应（PCR）法检测 TTV DNA。结果。平均年龄为 38.7±14.7 岁。71 名受试者（66%）为男性。108 例中，30 例（27.8%）TTV 阳性，78 例（72.2%）TTV 阴性。IDUs 中 TTV 的流行率[21（58%）]明显高于其他两组[第 I 组：6（17%）和第 III 组：3（8%）]（P<0.0001）。结论。IDUs 中 TTV 的流行率明显高于伊朗伊斯法罕的血液透析患者和普通人群。似乎有必要采取严厉措施，降低 TTV 传播给 IDUs 密切接触者和卫生保健提供者的风险。
