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鼠胎的相衬 X 射线显微断层成像术。

Phase-contrast X-ray microtomography of mouse fetus.

机构信息

Japan Synchrotron Radiation Research Institute , SPring-8, 1-1-1 Kouto, Sayo, Hyogo 679-5198 , Japan.

出版信息

Biol Open. 2012 Mar 15;1(3):269-74. doi: 10.1242/bio.2012430. Epub 2012 Feb 10.

DOI:10.1242/bio.2012430
PMID:23213417
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3507284/
Abstract

A phase-contrast X-ray microtomography system using the Talbot imaging has been built at the SPring-8 synchrotron radiation facility. This system has much higher density resolution than absorption-based X-ray microtomography. The tomographic sections of formalin-fixed mouse fetuses obtained with this method clearly depict various organs without any staining at a pixel resolution of up to 5 µm. Since this technique allows us to obtain three-dimensional structural information without sectioning, it will be particularly useful to examine anomalies that take place during development. It can be also used to quantitatively measure volume and mass of organs during development.

摘要

利用泰伯成像技术，我们在日本同步辐射研究机构的 SPring-8 同步加速器上建立了一个相衬 X 射线显微断层成像系统。该系统比基于吸收的 X 射线显微断层成像具有更高的密度分辨率。用该方法获得的福尔马林固定的小鼠胎儿断层切片，在像素分辨率高达 5μm 的情况下，无需染色即可清晰地描绘出各种器官。由于该技术可以在不进行切片的情况下获得三维结构信息，因此它特别适用于研究发育过程中的异常情况。它还可以用于定量测量发育过程中器官的体积和质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/3507284/9a979e1421ba/bio-01-03-269-f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/3507284/e722416d03a7/bio-01-03-269-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/3507284/2121f1fe8a44/bio-01-03-269-f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/3507284/b9895e33ed64/bio-01-03-269-f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/3507284/ccd8b38403b2/bio-01-03-269-f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/3507284/f7f95f3a27e1/bio-01-03-269-f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/3507284/9a979e1421ba/bio-01-03-269-f06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/3507284/e722416d03a7/bio-01-03-269-f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/3507284/2121f1fe8a44/bio-01-03-269-f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/3507284/b9895e33ed64/bio-01-03-269-f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/3507284/ccd8b38403b2/bio-01-03-269-f04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/3507284/f7f95f3a27e1/bio-01-03-269-f05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8756/3507284/9a979e1421ba/bio-01-03-269-f06.jpg

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