Ueda Keiji, Ohsaki Eriko, Nakano Kazushi, Zheng Xin
Division of Virology, Department of Microbiology and Immunology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.
Leuk Res Treatment. 2011;2011:726964. doi: 10.4061/2011/726964. Epub 2011 Nov 20.
Among herpesviruses, γ-herpesviruses are supposed to have typical oncogenic activities. Two human γ-herpesviruses, Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), are putative etiologic agents for Burkitt lymphoma, nasopharyngeal carcinoma, and some cases of gastric cancers, and Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma (PEL) especially in AIDS setting for the latter case, respectively. Since such two viruses mentioned above are highly species specific, it has been quite difficult to prove their oncogenic activities in animal models. Nevertheless, the viral oncogenesis is epidemiologically and/or in vitro experimentally evident. This time, we investigated gene expression profiles of KSHV-oriented lymphoma cell lines, EBV-oriented lymphoma cell lines, and T-cell leukemia cell lines. Both KSHV and EBV cause a B-cell-originated lymphoma, but the gene expression profiles were typically classified. Furthermore, KSHV could govern gene expression profiles, although PELs are usually coinfected with KSHV and EBV.
在疱疹病毒中，γ-疱疹病毒被认为具有典型的致癌活性。两种人类γ-疱疹病毒，即爱泼斯坦-巴尔病毒（EBV）和卡波西肉瘤相关疱疹病毒（KSHV），分别被认为是伯基特淋巴瘤、鼻咽癌和部分胃癌病例，以及卡波西肉瘤、多中心性Castleman病和原发性渗出性淋巴瘤（PEL，尤其是在艾滋病背景下）的潜在病因。由于上述两种病毒具有高度的物种特异性，在动物模型中证明它们的致癌活性一直相当困难。然而，病毒致癌作用在流行病学和/或体外实验中是明显的。此次，我们研究了以KSHV为主的淋巴瘤细胞系、以EBV为主的淋巴瘤细胞系和T细胞白血病细胞系的基因表达谱。KSHV和EBV均可引发B细胞起源的淋巴瘤，但基因表达谱有典型分类。此外，尽管PEL通常同时感染KSHV和EBV，但KSHV仍可调控基因表达谱。
