He Hai-bo, Xu Jia, Xu Yuan-qing, Wang Hong-wu, Di Guo-jie, Li Shou-chao, Sun Zhi-wei, He Yu-min, Yuan Ding
College of Medical Sciences, Three Gorges University, Yichang 443002, China.
Zhong Yao Cai. 2012 May;35(5):744-9.
To investigate the cardioprotective effects of total saponin from Panax japonicus pretreating on acute myocardial ischemia injury induced by ligating coronary artery left anterior descending branch (LAD) in rats.
Rats were divided into sham group, model group and total saponin group. The treatment group was given total saponin of Panax japonicus. After pretreating for 7 days, the rats' acute myocardial ischemia model was induced by LAD. The electrocardiogram, hemodynamics, infarct size and histomorphology were assessed 12 h after LAD, the serum levels of phosphokinase (CK), lactate dehydrogenase (LDH), superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) were also measured.
Compared with the model group, total saponin from Panax japonicus significantly improved heart function, heart histomorphology, opposed ECG T wave decreased and decreased infarct size; Remarkably decreased the contents of LDH, CK and MDA, increased the activity of SOD, CAT.
Total saponin from Panax japonicus has cardioprotective effects on acute myocardial ischemic injury and the mechanism may be related to antioxidation.
探讨竹节参总皂苷预处理对大鼠冠状动脉左前降支结扎（LAD）所致急性心肌缺血损伤的心脏保护作用。
将大鼠分为假手术组、模型组和总皂苷组。治疗组给予竹节参总皂苷。预处理7天后，通过LAD诱导大鼠急性心肌缺血模型。在LAD术后12小时评估心电图、血流动力学、梗死面积和组织形态学，同时测定血清磷酸激酶（CK）、乳酸脱氢酶（LDH）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和丙二醛（MDA）水平。
与模型组相比，竹节参总皂苷显著改善心脏功能、心脏组织形态学，对抗心电图T波降低并减小梗死面积；显著降低LDH、CK和MDA含量，提高SOD、CAT活性。
竹节参总皂苷对急性心肌缺血损伤具有心脏保护作用，其机制可能与抗氧化作用有关。
