Persec Zoran, Buković Damir, Peršec Jasminka, Rako Duje, Ljubanović Danica, Starčević Vito, Zupić Tomislav, Pavić Mato
University of Zagreb, Dubrava University Hospital, Department of Urology, Zagreb, Croatia.
Coll Antropol. 2012 Sep;36(3):1045-7.
The clear cell variant urothelial carcinoma of urinary bladder is very rare and unusual neoplasm defined histologically by clear cell pattern and glycogen-rich cytoplasm. Our case of clear cell carcinoma was diagnosed with immunohistochemistry stain. A 72-year-old man, presented with painless macroscopic hematuria in November 2007. Evaluation revealed papillary tumor in urinary bladder. A transurethral resection of the bladder tumor (TUR-Bt) was performed. Histopatologic evaluation showed superficial transitional cell carcinoma and carcinoma in situ. On three month follow-up, a solitary pedunculated tumor was detected again in the left wall of the urinary bladder. A repeated transurethral resection of the bladder tumor (reTUR-Bt) was performed in February 2008. The pathological diagnosis was difficult due to diffuse clear cell appearance. Immunohistochemistry stain showed urothelial carcinoma and finally it was diagnosed as clear cell variant. Urothelial carcinoma has many variants that show a variety of appearances and characteristics. These should be well known for evaluation and optimal treatment.
膀胱透明细胞变型尿路上皮癌是一种非常罕见且不寻常的肿瘤，其组织学定义为具有透明细胞模式和富含糖原的细胞质。我们的透明细胞癌病例通过免疫组织化学染色得以诊断。一名72岁男性，于2007年11月出现无痛性肉眼血尿。检查发现膀胱有乳头状肿瘤。进行了经尿道膀胱肿瘤切除术（TUR-Bt）。组织病理学评估显示为浅表性移行细胞癌和原位癌。在三个月的随访中，再次在膀胱左壁检测到一个孤立的带蒂肿瘤。2008年2月再次进行了经尿道膀胱肿瘤切除术（reTUR-Bt）。由于弥漫性透明细胞表现，病理诊断困难。免疫组织化学染色显示为尿路上皮癌，最终诊断为透明细胞变型。尿路上皮癌有许多变型，表现出各种外观和特征。为了进行评估和最佳治疗，应熟知这些变型。
