直链和高效合成二硒代氨基甲酸酯。

Straightforward and highly efficient synthesis of diselenocarbamates.

机构信息

Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, Department of Polymer Science and Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, PR China.

出版信息

Org Lett. 2012 Dec 21;14(24):6170-3. doi: 10.1021/ol3028626. Epub 2012 Dec 5.

DOI:10.1021/ol3028626

PMID:23214480

Abstract

A highly efficient and simple synthesis of diselenocarbamates, based on a one-pot reaction of amines, CSe(2), and alkyl halides in the absence of a catalyst under solvent-free conditions, is reported. The first efficient synthesis of diselenocarbamates via Michael addition of electron-deficient alkenes with aliphatic amines and CSe(2) in solid media silica gel is also presented.

摘要

本文报道了一种在无溶剂条件下，通过胺、CSe(2)和卤代烷一锅反应，无需催化剂，高效、简便地合成二硒代氨基甲酸酯的方法。本文还首次提出了在硅胶固相中通过迈克尔加成反应，用缺电子烯烃与脂肪胺和 CSe(2)合成二硒代氨基甲酸酯的有效方法。