Department of Radiation Oncology, Chronic Pain Unit of the Dr. Negrin University Hospital, Las Palmas, Canary Islands, Spain.
J Altern Complement Med. 2013 May;19(5):453-8. doi: 10.1089/acm.2012.0273. Epub 2012 Dec 7.
Headache afflicts approximately 10%-15% of the general population. Mixed results are obtained from various therapies, usually drugs, but also oxygen inhalation, behavioral psychology, physical therapy, and peripheral or central neurostimulation. When refractory to treatment, it has severe impact on quality of life. OBJECTIVES/SUBJECTS: Five (5) patients are presented who had suffered from severe/persistent headache refractory to standard management (including 5-HT1 agonist triptan drugs) and were treated with ozone therapy.
Ozone administration was by major autohemotherapy. The procedure involved venous blood drawn into a sterile single-use glass bottle containing anticoagulant, gently mixed with an equal volume of O3/O2 gas mixture (prefiltered through a sterile 0.20-μm filter) and slowly reinfused back into the donor patient via the antecubital vein.
The analyzed parameters were analgesia requirements, days of sick leave due to headache, number of headache events, and pain intensity according to the visual analogue scale (VAS); these recorded at three time points: pre-ozone therapy, post-ozone therapy, and before the last follow-up (mean: 64.6±36.8 months).
The number of headache episodes pretreatment (n=80; range 5-200) was significantly decreased during the first 6 months post-treatment (n=0, range 0-1; p=0.042) and over the 6 months before the last follow-up visit (n=1, range 0-2; p=0.043). The corresponding VAS scores were 8.7±0.8 pretreatment versus 1.1±2.5 the 6 months post-treatment (p=0.003) and versus 3.1±3.3 the 6 months before last follow-up visit (p=0.036).
Ozone therapy decreased headache episodes and pain severity over a protracted period. This novel approach is effective and merits further research.
头痛影响大约 10%-15%的普通人群。各种治疗方法（通常是药物，但也包括吸氧、行为心理学、物理治疗和外周或中枢神经刺激）的效果不一。当治疗无效时，它会严重影响生活质量。目的/对象：介绍 5 例严重/持续性头痛患者，这些患者对标准治疗（包括 5-HT1 激动剂曲坦类药物）无效，接受臭氧治疗。
臭氧治疗采用大剂量自体血疗法。该程序包括静脉采血到无菌一次性玻璃瓶中，加入抗凝剂，轻轻混合等体积的臭氧/氧气混合气体（预先通过无菌 0.20-μm 过滤器过滤），然后通过肘前静脉缓慢回输给供体患者。
分析的参数包括镇痛需求、因头痛而请病假的天数、头痛发作次数和疼痛强度（根据视觉模拟量表 [VAS]）；这些参数在三个时间点记录：臭氧治疗前、臭氧治疗后和最后一次随访前（平均：64.6±36.8 个月）。
治疗前头痛发作次数（n=80；范围 5-200）在治疗后 6 个月内显著减少（n=0，范围 0-1；p=0.042），并且在最后一次随访前 6 个月内也显著减少（n=1，范围 0-2；p=0.043）。相应的 VAS 评分分别为治疗前 8.7±0.8 与治疗后 6 个月时的 1.1±2.5（p=0.003）和最后一次随访前 6 个月时的 3.1±3.3（p=0.036）。
臭氧治疗可在较长时间内减少头痛发作次数和疼痛程度。这种新方法有效，值得进一步研究。
