University of Florida, College of Medicine, Division of Hematology/Oncology 1600 W Archer Road, Gainesville, FL 32610-0278, USA.
Expert Rev Hematol. 2012 Dec;5(6):661-9. doi: 10.1586/ehm.12.53.
Invasive fungal disease is associated with increased morbidity and mortality in hematologic malignancy patients and hematopoietic stem cell transplant recipients. Timely recognition and treatment of invasive fungal diseases in these patients are essential and decrease mortality. However, conventional definitive diagnostic methods are difficult and time consuming. While conventional microbiological and histopathological methods are still needed for a definitive diagnosis of invasive fungal disease, new noninvasive diagnostic methods including serologic and molecular biomarkers are now available. These new diagnostic methods facilitate an early diagnosis of invasive fungal disease and allow for utilization of a pre-emptive treatment approach, which may ultimately lead to improved treatment outcomes and reduced toxicity.
侵袭性真菌病与血液恶性肿瘤患者和造血干细胞移植受者的发病率和死亡率增加有关。及时识别和治疗这些患者的侵袭性真菌病至关重要，可以降低死亡率。然而，传统的明确诊断方法既困难又耗时。虽然传统的微生物学和组织病理学方法仍然是侵袭性真菌病明确诊断所必需的，但现在已有新的非侵入性诊断方法，包括血清学和分子生物标志物。这些新的诊断方法有助于早期诊断侵袭性真菌病，并允许采用先发制人的治疗方法，这可能最终导致改善治疗结果和降低毒性。
