Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Bünteweg 9, Hannover, 30559, Germany.
Ir Vet J. 2012 Dec 5;65(1):19. doi: 10.1186/2046-0481-65-19.
A seven-year old Australian Shepherd, suffering from idiopathic epilepsy under treatment with phenobarbitone and potassium bromide, was presented with generalised lower motor neuron signs. Electrophysiology and muscle-nerve biopsies revealed a neuromyopathy.The serum bromide concentration was increased more than two-fold above the upper reference value.Clinical signs disappeared after applying diuretics and reducing the potassium bromide dose rate. This is the first case report describing electrophysiological and histopathological findings associated with bromide induced lower motor neuron dysfunction in a dog.
一只七岁大的澳大利亚牧羊犬，患有特发性癫痫，正在接受苯巴比妥和溴化钾治疗，出现了全身性下运动神经元征象。电生理学和肌肉神经活检显示出一种神经肌肉疾病。血清溴化物浓度比参考值上限高出两倍以上。应用利尿剂和降低溴化钾剂量后，临床症状消失。这是首例描述犬溴化物诱导下运动神经元功能障碍的电生理和组织病理学发现的病例报告。
