Department of Pathology, the First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang 110001, China.
Diagn Pathol. 2012 Dec 7;7:172. doi: 10.1186/1746-1596-7-172.
Enteropathy-associated T-cell lymphoma (EATL) is a rare peripheral T-cell lymphoma which was classified into 2 types based on histology. EATL is often, but not always, associated with celiac disease. EATL type I is a large cell lymphoma which is more common in frequency and highly associated with celiac disease compared with type II. Jejunum and ileum are the common sites, although EATL can rarely occur in the duodenum, stomach and colon or outside the gastrointestinal tract. We herein presented one case of gastric EATL, which happened in a 73-year-old Chinese male patient. Histologically, the tumor was composed of polymorphic (pleomorphic, anaplastic, immunoblastic) lymphoid cells and numerous inflammatory cells, including histiocytes, neutrophils and eosinophils in the background. The pleomorphic lymphoid cells were diffuse and strongly positive for CD3 and partially positive for CD30, while negative for CD4, CD5, CD8 or CD56. The gastric EATL should be distinguished from other gastric lesions, such as peptic ulcer, poorly-differentiated adenocarcinoma and other types of lymphoma.
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1174320824810970.
肠病相关 T 细胞淋巴瘤（EATL）是一种罕见的外周 T 细胞淋巴瘤，根据组织学可分为 2 种类型。EATL 通常但不总是与乳糜泻有关。EATL 型 I 是一种大细胞淋巴瘤，与 II 型相比，其频率更高，且与乳糜泻高度相关。空肠和回肠是常见部位，尽管 EATL 也很少发生在十二指肠、胃和结肠或胃肠道外。本文报告了一例胃 EATL，发生在一名 73 岁的中国男性患者。组织学上，肿瘤由多形性（多形性、间变性、免疫母细胞性）淋巴样细胞和大量炎症细胞组成，背景中有组织细胞、中性粒细胞和嗜酸性粒细胞。多形性淋巴样细胞弥漫性强阳性表达 CD3，部分阳性表达 CD30，而阴性表达 CD4、CD5、CD8 或 CD56。胃 EATL 应与其他胃病变区分开来，如消化性溃疡、低分化腺癌和其他类型的淋巴瘤。
本文的虚拟幻灯片可在此处找到：http://www.diagnosticpathology.diagnomx.eu/vs/1174320824810970。
