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胃罕见单形性上皮样肠道T细胞淋巴瘤伴巨大胃穿孔,采用覆盖肝脏缝合术挽救,随后行全胃切除术和肝左外叶切除术:1例报告

Rare monomorphic epithelial intestinal T-cell lymphoma of the stomach with a giant gastric perforation rescued by liver-covering sutures followed by a total gastrectomy and lateral hepatectomy: a case report.

作者信息

Muramoto Keiji, Kaida Sachiko, Miyake Toru, Nishimura Rie, Kito Katsuyuki, Shiohara Masanori, Kushima Ryoji, Shimizu Tomoharu, Tani Masaji

机构信息

Department of Surgery, Shiga University of Medical Science, Seta, Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.

Department of Gastroenterology and Hematology, Shiga University of Medical Science, Seta, Tsukinowa-cho, Otsu, Shiga, 520-2192, Japan.

出版信息

Surg Case Rep. 2022 Feb 7;8(1):27. doi: 10.1186/s40792-022-01381-1.

Abstract

BACKGROUND

Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), a type of peripheral T-cell lymphoma, rarely involves the stomach as the primary organ. Advanced MEITL, for which there is currently no established treatment, causes gastrointestinal perforations and is characterized by a poor response to chemotherapy.

CASE PRESENTATION

A 69-year-old man had undergone chemotherapy for MEITL of the whole stomach. He subsequently developed acute abdominal pain, and computed tomography revealed a giant perforation in the anterior gastric wall adjacent to the lateral segment of the liver. The perforation was rescued through closure with liver-covering sutures. Thereafter, a total gastrectomy and a left hepatectomy were performed and he recovered enough to tolerate oral intake. However, despite ongoing chemotherapy, the patient died 83 days after the gastric perforation (10 months after being diagnosed with the lymphoma) owing to rapid progression of the MEITL.

CONCLUSION

In the rare case of a giant gastric perforation after chemotherapy for gastric MEITL, rescue is possible through liver-covering sutures followed by a total gastrectomy and lateral hepatectomy.

摘要

背景

单形性上皮样肠道T细胞淋巴瘤(MEITL)是一种外周T细胞淋巴瘤,很少以胃作为主要受累器官。晚期MEITL目前尚无既定的治疗方法,可导致胃肠道穿孔,且对化疗反应较差。

病例介绍

一名69岁男性因全胃MEITL接受了化疗。随后他出现急性腹痛,计算机断层扫描显示肝外侧段附近的胃前壁有巨大穿孔。通过覆盖肝脏的缝合进行穿孔修补。此后,进行了全胃切除术和左肝切除术,他恢复到足以耐受经口进食。然而,尽管持续化疗,该患者在胃穿孔后83天(淋巴瘤诊断后10个月)因MEITL快速进展而死亡。

结论

在胃MEITL化疗后出现巨大胃穿孔的罕见情况下,通过覆盖肝脏的缝合,随后进行全胃切除术和肝外侧叶切除术,有可能实现挽救。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/699d/8821748/dc2e3ad85b7d/40792_2022_1381_Fig1_HTML.jpg

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