Calzada-Reyes Ana, Alvarez-Amador Alfredo, Galán-García Lídice, Valdés-Sosa Mitchell
Department of Clinical Neurophysiology, Institute of Legal Medicine, Independence Avenue, Plaza, Havana City, Cuba.
J Forensic Leg Med. 2013 Jan;20(1):19-26. doi: 10.1016/j.jflm.2012.04.027. Epub 2012 May 16.
Previous EEG studies attempted to examine violent behavior as homogeneous construct. Up to date, there is no other research studying Low-Resolution Brain Electromagnetic Tomography (LORETA) technique in psychopath offenders.
To find electrophysiological differences specifically related to the psychopathy construct and independent of the violent behavior. The current investigation compares the QEEG and the current source density measures of violent psychopath offenders to a non-psychopath violent group.
The resting EEG activity and LORETA for the EEG spectral fast bands were evaluated in 58 violent offenders, 31 with and 27 without psychopathy according to the Hare Psychopathy Checklist - Revised. All subjects were assessed using the DSM IV-R criteria. The EEG visual inspection characteristics and the use of frequency domain quantitative analysis techniques (Narrow band spectral parameters) are described.
QEEG analysis showed a pattern of excess of beta activity on the left parieto-temporal regions and bilateral occipital areas and decrease of alpha band on the left centro-temporal and parieto-central derivations in the psychopath group. LORETA signified an increase of beta activity (17.18 Hz) in psychopath group relative to a non- psychopath group within fronto-temporo-limbic regions.
These findings indicate that QEEG analysis and techniques of source localization may reveal differences in brain electrical activity among offenders with psychopathy, which was not obvious to visual inspection. Taken together, these results suggest that abnormalities in a fronto-temporo-limbic network play a relevant role in the neurobiological basis of psychopathy.
以往的脑电图研究试图将暴力行为作为一个同质结构来研究。迄今为止，尚无其他研究在患有精神疾病的罪犯中使用低分辨率脑电磁断层扫描（LORETA）技术。
找出与精神疾病结构具体相关且独立于暴力行为的电生理差异。当前的研究将暴力型精神疾病罪犯的定量脑电图（QEEG）和电流源密度测量结果与非精神疾病暴力组进行比较。
根据修订版的 Hare 精神病态检查表，对 58 名暴力罪犯进行静息脑电图活动和脑电图频谱快速频段的 LORETA 评估，其中 31 名患有精神疾病，27 名未患精神疾病。所有受试者均按照《精神疾病诊断与统计手册》第四版修订版标准进行评估。描述了脑电图的视觉检查特征以及频域定量分析技术（窄带频谱参数）的使用情况。
QEEG 分析显示，精神病态组左侧顶颞区和双侧枕区的β活动过多，左侧中央颞区和顶中央导联的α波段减少。LORETA 表明，相对于非精神病态组，精神病态组额颞边缘区域的β活动（17.18Hz）有所增加。
这些发现表明，QEEG 分析和源定位技术可能揭示出患有精神疾病的罪犯大脑电活动的差异，而这些差异通过视觉检查并不明显。综上所述，这些结果表明额颞边缘网络的异常在精神疾病的神经生物学基础中起相关作用。
