Department of Exercise Sciences, Brigham Young University, Provo, Utah 84602, USA.
Br J Nutr. 2013 Jul 28;110(2):375-83. doi: 10.1017/S0007114512004953. Epub 2012 Dec 7.
The present study was conducted to determine the association between fibre intake and insulin resistance in 264 women using a cross-sectional design. Insulin resistance was indexed using homeostasis model assessment of insulin resistance (HOMA-IR) (US formula: fasting insulin (μU/ml) × fasting glucose (mg/dl)/405 international formula: fasting glucose (mmol/l) × fasting insulin (μU/l)/22.5). Fibre and energy consumption were assessed using 7 d weighed food records. Fibre was expressed as g/4184 kJ (1000 kcal). Body fat percentage (BF%) was measured using the BOD POD, and physical activity (PA) was ascertained using Actigraph accelerometers (Health One Technology) worn for seven consecutive days. Women with high total fibre intakes (F= 4·58, P= 0·0332) or high soluble fibre intakes (F= 7·97, P= 0·0051) had significantly less insulin resistance than their counterparts. Participants with high insoluble fibre intakes did not differ from their counterparts (F= 0·7, P= 0·6875). Adjusting for either PA or BF% weakened the relationships significantly. Controlling for BF% nullified the total fibre–HOMA-IR link (F= 1·96, P= 0·1631) and attenuated the association between soluble fibre and HOMA-IR by 32 % (F= 6·86, P= 0·0094). To create dichotomous variables, fibre intake and HOMA-IR were each divided into two categories using the median (low and high). In women who had high soluble fibre intake (upper 50 %), the OR of having an elevated HOMA-IR level was 0·58 (95 % CI 0·36, 0·94) times that of women with low soluble fibre intake (lower 50 %). After controlling for all of the potential confounding factors simultaneously, the OR was 0·52 (95 % CI 0·29, 0·93). High fibre intake, particularly soluble fibre, is significantly related to lower levels of insulin resistance in women. Part of this association is a function of differences in PA and BF%.
本研究采用横断面设计，在 264 名女性中，旨在确定膳食纤维摄入量与胰岛素抵抗之间的关系。采用稳态模型评估胰岛素抵抗指数（HOMA-IR）（美国公式：空腹胰岛素（μU/ml）×空腹血糖（mg/dl）/405；国际公式：空腹血糖（mmol/l）×空腹胰岛素（μU/l）/22.5）来评估胰岛素抵抗。膳食纤维和能量消耗通过 7 天的称重食物记录来评估。膳食纤维表示为 g/4184 kJ（1000 kcal）。体脂百分比（BF%）采用 BOD POD 测量，身体活动（PA）通过 Health One Technology 的 Actigraph 加速度计连续 7 天测量。高总膳食纤维摄入量（F=4.58，P=0.0332）或高可溶性膳食纤维摄入量（F=7.97，P=0.0051）的女性，其胰岛素抵抗明显低于对照组。高不溶性膳食纤维摄入量的参与者与对照组无差异（F=0.7，P=0.6875）。调整 PA 或 BF%后，这些关系显著减弱。控制 BF%消除了总膳食纤维与 HOMA-IR 之间的联系（F=1.96，P=0.1631），并使可溶性纤维与 HOMA-IR 之间的关联减弱了 32%（F=6.86，P=0.0094）。为了创建二分类变量，膳食纤维摄入量和 HOMA-IR 均使用中位数（低和高）分为两类。在可溶性纤维摄入量高（上 50%）的女性中，HOMA-IR 水平升高的 OR 为 0.58（95%CI 0.36，0.94），而可溶性纤维摄入量低（下 50%）的女性为 1.00。在同时控制所有潜在混杂因素后，OR 为 0.52（95%CI 0.29，0.93）。高膳食纤维摄入，尤其是可溶性膳食纤维，与女性较低的胰岛素抵抗水平显著相关。这种关联的一部分是由于 PA 和 BF%的差异所致。
