Innovation Center for Health Promotion, Graduate School of Medicine, Hirosaki University, Hirosaki 036-8562, Japan.
Health Science Research Center, FANCL Research Institute, Yokohama 244-0806, Japan.
Int J Environ Res Public Health. 2022 Jul 31;19(15):9391. doi: 10.3390/ijerph19159391.
The correlation between diabetes-related biomarkers and quality of life (QOL) remains unclear. In this cross-sectional study, we investigated the correlation between diabetes-related biomarkers and QOL in a general Japanese population who underwent health checkups as a part of the Iwaki Health Promotion Project. Male and female participants aged ≥ 20 years from Iwaki District, Hirosaki City, Aomori Prefecture who participated in the 2019 medical evaluation were recruited. QOL was evaluated using the Short Form Health Survey 36 (SF-36). Fasting blood glucose, homeostatic model assessment-estimated insulin resistance (HOMA-IR), hemoglobin A1c (HbA1c), glycoalbumin, and plasma pentosidine were also evaluated as diabetes-related markers. Of the 1065 recruited participants, 1053 completed the clinical and QOL evaluations. Multivariate regression analysis revealed that upregulated diabetes-related markers levels were correlated with decreased SF-36 scores. Blood glucose, HOMA-IR, HbA1c, glycoalbumin, and plasma pentosidine levels were correlated with general health. Moreover, plasma pentosidine levels were correlated with role physical, social functioning, and role emotional in addition to general health. These results indicated that the levels of diabetes-related biomarkers, particularly the levels of plasma pentosidine, a glycation marker, were associated with QOL in our cohort.
糖尿病相关生物标志物与生活质量（QOL）之间的相关性尚不清楚。在这项横断面研究中，我们调查了一般日本人群中糖尿病相关生物标志物与生活质量之间的相关性，这些人群是作为岩木健康促进计划的一部分接受健康检查的。我们招募了来自青森县弘前市岩木地区、年龄≥ 20 岁且参加了 2019 年医学评估的男性和女性参与者。使用健康调查简表 36 项（SF-36）评估生活质量。还评估了空腹血糖、稳态模型评估估计的胰岛素抵抗（HOMA-IR）、糖化血红蛋白（HbA1c）、糖基化白蛋白和血浆戊糖，作为糖尿病相关标志物。在招募的 1065 名参与者中，有 1053 名完成了临床和生活质量评估。多变量回归分析显示，上调的糖尿病相关标志物水平与 SF-36 评分降低相关。血糖、HOMA-IR、HbA1c、糖基化白蛋白和血浆戊糖水平与一般健康状况相关。此外，血浆戊糖水平与一般健康以及身体角色、社会功能和情感角色相关。这些结果表明，在我们的队列中，糖尿病相关生物标志物的水平，特别是糖化标志物血浆戊糖的水平，与生活质量相关。
