从分子到建模：人类-动物-环境界面中的刚地弓形虫卵囊。
Molecules to modeling: Toxoplasma gondii oocysts at the human-animal-environment interface.
机构信息
One Health Institute, School of Veterinary Medicine, University of California-Davis, 1 Shields Avenue, Davis, CA 95616, USA.
出版信息
Comp Immunol Microbiol Infect Dis. 2013 May;36(3):217-31. doi: 10.1016/j.cimid.2012.10.006. Epub 2012 Dec 4.
Abstract
Environmental transmission of extremely resistant Toxoplasma gondii oocysts has resulted in infection of diverse species around the world, leading to severe disease and deaths in human and animal populations. This review explores T. gondii oocyst shedding, survival, and transmission, emphasizing the importance of linking laboratory and landscape from molecular characterization of oocysts to watershed-level models of oocyst loading and transport in terrestrial and aquatic systems. Building on discipline-specific studies, a One Health approach incorporating tools and perspectives from diverse fields and stakeholders has contributed to an advanced understanding of T. gondii and is addressing transmission at the rapidly changing human-animal-environment interface.
摘要
环境传播的极为耐药的刚地弓形虫卵囊已导致世界各地多种物种感染，导致人类和动物群体中出现严重疾病和死亡。本综述探讨了刚地弓形虫卵囊的脱落、存活和传播，强调了将实验室和景观联系起来的重要性，从卵囊的分子特征到陆地和水生系统中卵囊负荷和运输的流域水平模型。在学科特定研究的基础上，纳入来自不同领域和利益相关者的工具和观点的一种健康方法有助于提高对刚地弓形虫的认识，并正在迅速变化的人类-动物-环境界面解决传播问题。
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