Department of Polymer Engineering, Amirkabir University of Technology, PO Box 15875/4413, Tehran, Iran.
Carbohydr Polym. 2013 Jan 30;92(1):48-56. doi: 10.1016/j.carbpol.2012.09.002. Epub 2012 Sep 7.
The objective of this work was to prepare chitosan/polyethylene glycol fumarate (chitosan/PEGF) blend films as wound dressings and to evaluate the influence of composition ratio on the blending properties of the films. Blending chitosan with PEGF obviated the brittleness of neat chitosan film. Film topography performed by atomic force microscopy illustrated that blending could increase and control the surface roughness of the neat film. Their water vapor transmission rates were close to the range of 904-1447 g(-2)day(-1) found to be proper candidates for dressing the wounds with moderate exudates. Controlled water solubility, swelling, wettability and surface tension of the blend films were also evaluated. The blend films showed a powerful antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus (Kill%>99.76 ± 0.16%). Physical properties as well as antibacterial activity assessments showed that among different compositions, the film comprising 80 wt% chitosan and 20 wt% PEGF is a suitable candidate for biomedical applications as a wound dressing material.
本工作旨在制备壳聚糖/聚乙二醇富马酸（壳聚糖/PEGF）共混膜作为伤口敷料，并评估组成比对膜混合性能的影响。将壳聚糖与 PEGF 共混可以克服纯壳聚糖膜的脆性。原子力显微镜进行的薄膜形貌表明，共混可以增加并控制纯膜的表面粗糙度。它们的水蒸气透过率接近合适的范围（904-1447 g(-2)day(-1)），适合用于有中等渗出液的伤口敷料。还评估了共混膜的控制水溶性、溶胀性、润湿性和表面张力。共混膜对铜绿假单胞菌和金黄色葡萄球菌具有强大的抗菌活性（杀灭率>99.76 ± 0.16%）。物理性能和抗菌活性评估表明，在不同组成中，包含 80wt%壳聚糖和 20wt% PEGF 的膜是作为伤口敷料材料的生物医学应用的合适候选者。
