Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran.
Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran.
Mater Sci Eng C Mater Biol Appl. 2017 Oct 1;79:66-75. doi: 10.1016/j.msec.2017.05.001. Epub 2017 May 3.
In the present study, polyethylene glycol fumarate (PEGF) was synthesized as a component of blend solutions via polycondensation polymerization and characterized by different tests in order to determine its functional groups and its physical properties included melting and crystallization temperature, enthalpy of fusion and average molecular weights. Wound dressing films based on chitosan (Ch), PEGF and thymol (Th) were fabricated by solvent casting method with different formulations contained 80%(w/w) chitosan and 20%(w/w) PEGF as polymeric components and different amounts of thymol consisted of 0, 0.6, 1.2 and 1.8%(v/v) as pharmaceutical additives of blend solutions. These films were evaluated by different essential tests included Fourier transform infrared spectroscopy (FTIR), tensile testing, water vapor transmission rate (WVTR), water vapor uptake, equilibrium water uptake, water solubility, swelling, scanning electron microscopy (SEM) and antibacterial activity tests. The blend film contained 1.8%(v/v) thymol demonstrated optimal properties included acceptable mechanical properties, better absorption of water vapor or liquid water, higher water vapor transmission rate and air permeability, acceptable water solubility, superior swelling level, more porous structures and rough surfaces and the excellent antibacterial activity against both gram-negative and gram-positive bacteria which make it a suitable candidate for wound dressing applications.
在本研究中，聚乙二醇富马酸酯（PEGF）通过缩聚聚合被合成作为共混溶液的组成部分，并通过不同的测试进行了表征，以确定其官能团及其物理性质，包括熔融和结晶温度、熔融焓和平均分子量。基于壳聚糖（Ch）、PEGF 和百里香酚（Th）的伤口敷贴膜通过溶剂浇铸法制备，不同配方包含 80%（w/w）壳聚糖和 20%（w/w）PEGF 作为聚合物成分，以及不同量的百里香酚，分别为 0、0.6、1.2 和 1.8%（v/v）作为共混溶液的药物添加剂。这些薄膜通过不同的基本测试进行了评估，包括傅里叶变换红外光谱（FTIR）、拉伸测试、水蒸气透过率（WVTR）、水蒸气吸收、平衡吸水率、水溶性、溶胀、扫描电子显微镜（SEM）和抗菌活性测试。含 1.8%（v/v）百里香酚的共混膜表现出最佳性能，包括可接受的机械性能、更好的水蒸气或液态水吸收、更高的水蒸气透过率和透气性、可接受的水溶性、更高的溶胀水平、更多孔的结构和粗糙的表面以及对革兰氏阴性菌和革兰氏阳性菌的优异抗菌活性，使其成为伤口敷贴应用的合适候选物。
