涂层作为预防植入物相关感染的有效药物递送系统。
Coatings as the useful drug delivery system for the prevention of implant-related infections.
作者信息
Pan Chenhao, Zhou Zubin, Yu Xiaowei
机构信息
Department of Orthopaedic Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, 200233, China.
Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital East Campus, Shanghai University of Medicine and Health Sciences, Shanghai, 201306, China.
出版信息
J Orthop Surg Res. 2018 Sep 3;13(1):220. doi: 10.1186/s13018-018-0930-y.
Abstract
Implant-related infections (IRIs) which led to a large amount of medical expenditure were caused by bacteria and fungi that involve the implants in the operation or in ward. Traditional treatments of IRIs were comprised of repeated radical debridement, replacement of internal fixators, and intravenous antibiotics. It needed a long time and numbers of surgeries to cure, which meant a catastrophe to patients. So how to prevent it was more important than to cure it. As an excellent local release system, coating is a good idea by its local drug infusion and barrier effect on resisting biofilms which were the main cause of IRIs. So in this review, materials used for coatings and evidences of prevention were elaborated.
摘要
植入物相关感染（IRIs）会导致大量医疗支出，它是由手术或病房中涉及植入物的细菌和真菌引起的。IRIs的传统治疗方法包括反复进行彻底清创、更换内固定器以及静脉注射抗生素。治愈这种疾病需要很长时间且要进行多次手术，这对患者来说是一场灾难。因此，如何预防它比治愈它更为重要。作为一种出色的局部释放系统，涂层通过局部药物输注以及对抵抗生物膜（IRIs的主要成因）的屏障作用，是个不错的办法。所以在本综述中，阐述了用于涂层的材料及预防的证据。
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